Tuuri Rachel E, Wright Joseph L, He Jianping, McCarter Robert J, Ryan Leticia M
Division of Pediatric Emergency Medicine, Medical University of South Carolina, Charleston, SC, USA.
Pediatr Emerg Care. 2011 Nov;27(11):1045-51. doi: 10.1097/PEC.0b013e318235ea02.
A poison center plays an important role in directing appropriate care, which is critical in reducing morbidity due to poisoning. Activated charcoal (AC) is one intervention for some poisonings. This study examined whether children with a poisoning who were preannounced by a poison center received AC earlier than patients without a referral.
A retrospective review of AC administration in children aged 0 to 18 years in a pediatric emergency department (ED) from 2000 to 2006 was performed. Abstracted covariates were poison center referral status, age, sex, acuity, disposition, transportation mode, triage time, and time of AC administration. Analysis of variance controlling for covariates tested the equality of mean time intervals between the groups with and without a poison center referral.
Three hundred fifty-one cases met the inclusion criteria. One hundred thirty-five (39%) were male. Eighty cases (23%) had a poison center referral. Time from triage to charcoal administration for patients with a poison center referral was a mean of 59 (SD, 34) minutes. Time for the group without a referral was a mean of 71 (SD, 43) minutes (P = 0.0036).
Advanced communication from a poison center was associated with earlier administration of AC in the ED for this population. Nevertheless, the duration to charcoal administration was frequently suboptimal. Triage and prehospital practices should be reexamined to improve timeliness of AC when indicated and consider exclusion of administration if beyond an appropriate time frame. Advanced notification should be the paradigm for all poison centers, and early response protocols for poison center referrals should be used by EDs.
中毒控制中心在指导恰当治疗方面发挥着重要作用,这对于降低中毒所致发病率至关重要。活性炭(AC)是针对某些中毒情况的一种干预措施。本研究旨在探讨由中毒控制中心预先通报的中毒儿童是否比未转诊的患者更早接受活性炭治疗。
对2000年至2006年期间一家儿科急诊科(ED)中0至18岁儿童的活性炭使用情况进行回顾性研究。提取的协变量包括中毒控制中心转诊状态、年龄、性别、病情严重程度、处置方式、交通方式、分诊时间以及活性炭给药时间。控制协变量的方差分析检验了有或没有中毒控制中心转诊的两组之间平均时间间隔的相等性。
351例病例符合纳入标准。其中135例(39%)为男性。80例(23%)有中毒控制中心转诊。有中毒控制中心转诊的患者从分诊到给予活性炭的时间平均为59(标准差,34)分钟。未转诊组的时间平均为71(标准差,43)分钟(P = 0.0036)。
中毒控制中心的提前沟通与该人群在急诊科更早给予活性炭治疗相关。然而,给予活性炭的时间往往未达到最佳。应重新审视分诊和院前操作,以在有指征时提高活性炭给药的及时性,并考虑在超出适当时间范围时排除给药。提前通知应成为所有中毒控制中心的范例,急诊科应采用针对中毒控制中心转诊的早期应对方案。