Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Avenida das Américas 1155, Room 504, CEP 22631-000, Rio de Janeiro, Brazil.
Curr Pain Headache Rep. 2012 Feb;16(1):80-5. doi: 10.1007/s11916-011-0229-8.
Medication-overuse headache (MOH) is a relatively common and impactful disorder, affecting 1% to 2% of the population, characterized by daily or near-daily headache aggravated by chronic acute medication intake. Primary headache patients do not necessarily develop MOH after acute medication overuse, although a pre-existing primary headache is inevitably present. Likewise, headache patients may deteriorate in terms of frequency without medication overuse, or suffer from chronic headache in the presence of drug abuse without any causal relationship. To classify and define diagnostic criteria for MOH in the absence of objective biomarkers is a difficult task that is presently based on clinical grounds and is limited in part by the relative lack of research in this field. The present criteria are less restrictive but also less precise than the previous versions because they allow the diagnosis without the previously required MOH confirmation after medication withdrawal. MOH should remain as a distinct secondary disorder based on the available clinical and pathophysiological evidence.
药物过度使用性头痛（MOH）是一种相对常见且影响较大的疾病，影响 1%至 2%的人口，其特征是慢性急性药物摄入加重的每日或接近每日头痛。原发性头痛患者在急性药物过度使用后不一定会发展为 MOH，尽管必然存在原发性头痛。同样，头痛患者可能会在没有药物过度使用的情况下恶化频率，或者在没有任何因果关系的情况下滥用药物而患有慢性头痛。在没有客观生物标志物的情况下对 MOH 进行分类和定义诊断标准是一项艰巨的任务，目前基于临床依据，部分原因是该领域的研究相对较少。目前的标准限制较少，但也不那么精确，因为它们允许在不需要以前规定的停药后 MOH 确认的情况下进行诊断。根据现有临床和病理生理学证据，MOH 应仍然是一种明确的继发性疾病。
