单硫代丙二酸盐作为硫酯烯醇化物等价物-在温和条件下对硝基烯烃的对映选择性 1,4-加成反应。
Mono thiomalonates as thioester enolate equivalents--enantioselective 1,4-addition reactions to nitroolefins under mild conditions.
机构信息
Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
出版信息
Org Biomol Chem. 2012 Jan 7;10(1):110-3. doi: 10.1039/c1ob06638b. Epub 2011 Nov 8.
PMID:22068641
Abstract
Mono thiomalonates (MTMs) are introduced as thioester enolate equivalents. Asymmetric organocatalyzed conjugate addition reactions to nitroolefins proceed under mild conditions to afford synthetically useful γ-nitrothioesters with excellent yields and enantioselectivities.
摘要
单硫代丙二酸盐（MTMs）被引入作为硫代烯醇酯等价物。不对称有机催化的共轭加成反应到硝基烯烃在温和条件下进行，以优异的收率和对映选择性得到合成上有用的γ-硝基硫代酯。
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