Xu Dan-Qian, Yue Hua-Dong, Luo Shu-Ping, Xia Ai-Bao, Zhang Shuai, Xu Zhen-Yuan
State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou, 310014, China.
Org Biomol Chem. 2008 Jun 21;6(12):2054-7. doi: 10.1039/b804541k. Epub 2008 May 16.
A novel and effective organocatalytic system consisting of pyrrolidinyl-thioimidazole and a chiral thioureido acid efficiently catalyzed the asymmetric Michael addition reactions of ketones to nitroolefins to afford the adducts with high diastereoselectivities (up to 99 : 1) and excellent enantioselectivities (up to 99% ee).
一种由吡咯烷基硫代咪唑和手性硫脲酸组成的新型高效有机催化体系，能有效催化酮与硝基烯烃的不对称迈克尔加成反应，以高非对映选择性（高达99:1）和优异的对映选择性（高达99% ee）得到加合物。
