Academic Unit of Mental Health and Wellbeing, University of Glasgow, UK.
Int J Geriatr Psychiatry. 2012 Jul;27(7):659-69. doi: 10.1002/gps.2771. Epub 2011 Nov 8.
To review the evidence relating to the diagnostic accuracy and clinical utility of the Addenbrooke's Cognitive Examination (ACE) and its updated version, the Addenbrooke's Cognitive Examination-Revised (ACE-R) in relation to the diagnosis of dementia.
A systematic search of relevant databases was conducted, covering the period 2000 to April 2010. Specific journals and reference lists were hand searched. Identified studies that fulfilled the inclusion criteria were reviewed using a tailored, methodological quality rating checklist.
The systematic search process identified nine studies for review (seven relating to the ACE, two on the ACE-R). Strengths and weaknesses across studies are considered, and diagnostic accuracy measures are presented for six out of the nine studies.
The evidence suggests that the ACE/ACE-R is capable of providing information on a range of cognitive domains and of differentiating well between those with and those without cognitive impairment. Further research examining how the tools distinguish between dementia subtypes and mild cognitive impairment will further benefit the evidence base.
回顾与痴呆诊断相关的阿登布鲁克认知测验（ACE）及其更新版本阿登布鲁克认知测验修订版（ACE-R）的诊断准确性和临床实用性的证据。
对 2000 年至 2010 年 4 月期间的相关数据库进行了系统搜索，并对特定的期刊和参考文献进行了手工搜索。使用专门的、方法学质量评分检查表对符合纳入标准的研究进行了综述。
系统搜索过程共确定了 9 项研究进行综述（7 项与 ACE 相关，2 项与 ACE-R 相关）。考虑了研究之间的优缺点，并为其中 6 项研究提供了诊断准确性指标。
证据表明，ACE/ACE-R 能够提供一系列认知领域的信息，并能很好地区分有认知障碍和无认知障碍的人群。进一步研究如何区分痴呆亚型和轻度认知障碍将进一步丰富证据基础。
