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本文引用的文献

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Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the singapore malay eye study.眼灌注压分布及其与开角型青光眼的关系：新加坡马来人眼研究。
Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3399-404. doi: 10.1167/iovs.09-4867. Epub 2010 Feb 17.
2
Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study.中国成年人中主要眼部疾病及与系统性高血压相关的危险因素：北京眼病研究
Ophthalmology. 2009 Dec;116(12):2373-80. doi: 10.1016/j.ophtha.2009.05.041. Epub 2009 Oct 7.
3
Primary open-angle glaucoma.原发性开角型青光眼
N Engl J Med. 2009 Mar 12;360(11):1113-24. doi: 10.1056/NEJMra0804630.
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Screening for open angle glaucoma: systematic review of cost-effectiveness studies.开角型青光眼筛查：成本效益研究的系统评价
J Glaucoma. 2008 Apr-May;17(3):159-68. doi: 10.1097/IJG.0b013e31814b9693.
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Risk factors for incident open-angle glaucoma: the Barbados Eye Studies.原发性开角型青光眼发病的危险因素：巴巴多斯眼科研究
Ophthalmology. 2008 Jan;115(1):85-93. doi: 10.1016/j.ophtha.2007.03.017. Epub 2007 Jul 16.
6
Systemic antihypertensive medication and incident open-angle glaucoma.全身性抗高血压药物与原发性开角型青光眼的发病
Ophthalmology. 2007 Dec;114(12):2221-6. doi: 10.1016/j.ophtha.2007.03.047. Epub 2007 Jun 12.
7
Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study.日本人群开角型青光眼的危险因素：多治见研究
Ophthalmology. 2006 Sep;113(9):1613-7. doi: 10.1016/j.ophtha.2006.03.059. Epub 2006 Jul 7.
8
Association of blood pressure status with the optic disk structure.
Am J Ophthalmol. 2006 Jul;142(1):144-5. doi: 10.1016/j.ajo.2006.03.049.
9
Association of blood pressure status with the optic disk structure in non-glaucoma subjects: the Thessaloniki eye study.非青光眼受试者的血压状态与视盘结构的关联：塞萨洛尼基眼病研究
Am J Ophthalmol. 2006 Jul;142(1):60-67. doi: 10.1016/j.ajo.2006.02.055.
10
A sick eye in a sick body? Systemic findings in patients with primary open-angle glaucoma.
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参加社区健康筛查的日本受试者原发性开角型青光眼的危险因素。

Risk factors for primary open-angle glaucoma in Japanese subjects attending community health screenings.

作者信息

Ishikawa Makoto, Sawada Yu, Sato Noriko, Yoshitomi Takeshi

机构信息

Department of Ophthalmology, Akita Graduate University School of Medicine, Akita, Japan.

出版信息

Clin Ophthalmol. 2011;5:1531-7. doi: 10.2147/OPTH.S26049. Epub 2011 Oct 20.

DOI:10.2147/OPTH.S26049
PMID:22069358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3206127/
Abstract

BACKGROUND/AIMS: To describe risk factors associated with primary open-angle glaucoma (POAG) in Japanese subjects who participated in community health screenings.

METHODS

Residents of Akita, Japan, participating in a community health checkup were selected to undergo a comprehensive ophthalmic examination. Glaucoma was diagnosed based on optic disk appearance, perimetric results, and other ocular findings. Systemic blood pressure and intraocular pressure were measured and ocular perfusion pressure was calculated. Logistic regression analysis was performed to determine risk factors for POAG patients.

RESULTS AND CONCLUSION

Of the 710 subjects examined, 26 had POAG. The estimated prevalence of POAG was 3.7%. After adjusting for age, the prevalence of POAG was similar to that found in the Tajimi Study of Japanese subjects. Multivariate logistic regression analysis demonstrated that older age (≥60 years, odds ratio [OR]: 3.49), lower diastolic blood pressure (≤58 mmHg, OR: 2.11), higher intraocular pressure (≥19 mmHg, OR: 4.12), and lower ocular perfusion pressure (≤34 mmHg, OR: 5.78) were associated with increased risk of having POAG. These findings may be relevant for identifying high risk groups.

摘要

背景/目的：描述参与社区健康筛查的日本受试者中与原发性开角型青光眼（POAG）相关的危险因素。

方法

选取日本秋田市参与社区健康检查的居民进行全面眼科检查。根据视盘外观、视野检查结果及其他眼部检查结果诊断青光眼。测量全身血压和眼压并计算眼灌注压。进行逻辑回归分析以确定POAG患者的危险因素。

结果与结论

在710名接受检查的受试者中，26人患有POAG。POAG的估计患病率为3.7%。在调整年龄后，POAG的患病率与对日本受试者进行的田研究中发现的患病率相似。多变量逻辑回归分析表明，年龄较大（≥60岁，比值比[OR]：3.49）、舒张压较低（≤58 mmHg，OR：2.11）、眼压较高（≥19 mmHg，OR：4.12）和眼灌注压较低（≤34 mmHg，OR：5.78）与患POAG的风险增加相关。这些发现可能有助于识别高危人群。