Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston 77030, TX, USA.
Toxins (Basel). 2010 Oct;2(10):2428-66. doi: 10.3390/toxins2102428. Epub 2010 Oct 22.
Traditional medicine and diet has served mankind through the ages for prevention and treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation mediates most chronic diseases, including cancer. More than other transcription factors, nuclear factor-kappaB (NF-κB) and STAT3 have emerged as major regulators of inflammation, cellular transformation, and tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Thus, agents that can inhibit NF-κB and STAT3 activation pathways have the potential to both prevent and treat cancer. In this review, we examine the potential of one group of compounds called triterpenes, derived from traditional medicine and diet for their ability to suppress inflammatory pathways linked to tumorigenesis. These triterpenes include avicins, betulinic acid, boswellic acid, celastrol, diosgenin, madecassic acid, maslinic acid, momordin, saikosaponins, platycodon, pristimerin, ursolic acid, and withanolide. This review thus supports the famous adage of Hippocrates, "Let food be thy medicine and medicine be thy food".
传统医学和饮食在过去的几个世纪中一直被用于预防和治疗大多数慢性疾病。越来越多的证据表明，慢性炎症介导了大多数慢性疾病，包括癌症。与其他转录因子相比，核因子-κB（NF-κB）和 STAT3 已成为炎症、细胞转化和肿瘤细胞存活、增殖、侵袭、血管生成和转移的主要调节因子。因此，能够抑制 NF-κB 和 STAT3 激活途径的药物具有预防和治疗癌症的潜力。在这篇综述中，我们研究了一组称为三萜的化合物的潜力，这些化合物来自传统医学和饮食，因其能够抑制与肿瘤发生相关的炎症途径。这些三萜包括莪术呋喃、齐墩果酸、乳香酸、雷公藤红素、薯蓣皂苷元、马桑内酯、齐墩果酸、知母皂甙、柴胡皂甙、远志酸、熊果酸和乌苏烷。因此，这篇综述支持了希波克拉底的名言：“让食物成为你的药物，药物成为你的食物”。
