Bio-Protection Research Centre, Institute of Molecular BioSciences, Massey University, Palmerston North, New Zealand.
Toxins (Basel). 2010 Nov;2(11):2680-98. doi: 10.3390/toxins2112680. Epub 2010 Nov 5.
Dothistroma needle blight is one of the most devastating fungal pine diseases worldwide. The disease is characterized by accumulation in pine needles of a red toxin, dothistromin, that is chemically related to aflatoxin (AF) and sterigmatocystin (ST). This review updates current knowledge of the genetics of dothistromin biosynthesis by the Dothistroma septosporum pathogen and highlights differences in gene organization and regulation that have been discovered between the dothistromin and AF/ST systems. Some previously reported genes are promoted or demoted as 'dothistromin genes' based on recent research. A new dothistromin gene, norB, is reported, and evidence of dothistromin gene homologs in other Dothideomycete fungi is presented. A hypothesis for the biological role of dothistromin is outlined. Finally, the impact that the availability of the D. septosporum genome sequence will have on dothistromin research is discussed.
道氏茎点霉枯梢病是世界范围内最具破坏性的真菌性松树疾病之一。该疾病的特征是在松针中积累一种红色毒素，道氏菌素，其在化学上与黄曲霉毒素（AF）和杂色曲霉素（ST）有关。本综述更新了道氏茎点霉病原体生物合成道氏菌素的遗传学的最新知识，并强调了在道氏菌素和 AF/ST 系统之间发现的基因组织和调控的差异。一些以前报道的基因根据最近的研究被提升或降级为“道氏菌素基因”。报道了一个新的道氏菌素基因 norB，并提出了其他隔孢腔菌真菌中道氏菌素基因同源物的证据。概述了道氏菌素的生物学作用假说。最后，讨论了 D. septosporum 基因组序列的可用性将对道氏菌素研究产生的影响。
