Division of Neurosurgery, Duke University Medical Center, Box 3807, Durham, NC 27710, USA.
Toxins (Basel). 2011 Mar;3(3):201-6. doi: 10.3390/toxins3030201. Epub 2011 Mar 15.
Drug delivery of immunotoxins to brain tumors circumventing the blood brain barrier is a significant challenge. Convection-enhanced delivery (CED) circumvents the blood brain barrier through direct intracerebral application using a hydrostatic pressure gradient to percolate therapeutic compounds throughout the interstitial spaces of infiltrated brain and tumors. The efficacy of CED is determined through the distribution of the therapeutic agent to the targeted region. The vast majority of patients fail to receive a significant amount of coverage of the area at risk for tumor recurrence. Understanding this challenge, it is surprising that so little work has been done to monitor the delivery of therapeutic agents using this novel approach. Here we present a review of imaging in convection enhanced delivery monitoring of toxins in humans, and discuss future challenges in the field.
将免疫毒素递送至脑肿瘤以绕过血脑屏障是一项重大挑战。通过使用静水压梯度直接进行脑内应用，对流增强输送（CED）绕过血脑屏障，使治疗化合物渗透到浸润的脑和肿瘤的间质空间中。CED 的功效通过治疗剂在目标区域的分布来确定。绝大多数患者未能获得大量覆盖肿瘤复发风险区域的治疗剂。尽管存在这一挑战，但令人惊讶的是，使用这种新方法监测治疗剂输送的工作却很少。在这里，我们回顾了在人类中使用对流增强输送监测毒素的成像，并讨论了该领域未来的挑战。
