Mehta Ankit I, Choi Bryan D, Ajay Divya, Raghavan Raghu, Brady Martin, Friedman Allan H, Pastan Ira, Bigner Darell D, Sampson John H
Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.
Curr Drug Discov Technol. 2012 Dec;9(4):305-10. doi: 10.2174/157016312803305951.
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.
血脑屏障（BBB）对将大分子药物输送到大脑构成了重大挑战。对流增强递送（CED）通过使用静水压力梯度进行直接脑内输注来绕过血脑屏障，以转移治疗性化合物。CED的疗效取决于治疗剂在目标区域的分布。在此，我们对大分子的对流增强递送进行综述，强调示踪剂在实现有效递送中的作用，并讨论该领域当前面临的挑战。
