对流增强大分子在脑肿瘤中的递送。
Convection enhanced delivery of macromolecules for brain tumors.
作者信息
Mehta Ankit I, Choi Bryan D, Ajay Divya, Raghavan Raghu, Brady Martin, Friedman Allan H, Pastan Ira, Bigner Darell D, Sampson John H
机构信息
Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Curr Drug Discov Technol. 2012 Dec;9(4):305-10. doi: 10.2174/157016312803305951.
Abstract
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.
摘要
血脑屏障（BBB）对将大分子药物输送到大脑构成了重大挑战。对流增强递送（CED）通过使用静水压力梯度进行直接脑内输注来绕过血脑屏障，以转移治疗性化合物。CED的疗效取决于治疗剂在目标区域的分布。在此，我们对大分子的对流增强递送进行综述，强调示踪剂在实现有效递送中的作用，并讨论该领域当前面临的挑战。
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