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脉络丛分泌细胞中的β-肾上腺素能敏感腺苷酸环化酶。

Beta-adrenergic-sensitive adenylate cyclase in secretory cells of choroid plexus.

作者信息

Nathanson J A

出版信息

Science. 1979 May 25;204(4395):843-4. doi: 10.1126/science.220707.

DOI:10.1126/science.220707
PMID:220707
Abstract

Biochemical evidence supporting the sympathetic control of cerebrospinal fluid production has been obtained through identification of a specific beta-adrenergic-sensitive adenylate cyclase in the choroid plexus. The enzyme, which is localized in the secretory epithelium, is activated by low concentrations of isoproterenol and norepinephrine and appears separate from beta-adrenergic-sensitive adenylate cyclase present in cerebral blood vessels.

摘要

通过在脉络丛中鉴定出一种特定的β-肾上腺素能敏感腺苷酸环化酶,已获得了支持交感神经对脑脊液生成进行控制的生化证据。这种酶定位于分泌上皮中,可被低浓度的异丙肾上腺素和去甲肾上腺素激活,且似乎与脑血管中存在的β-肾上腺素能敏感腺苷酸环化酶不同。

相似文献

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Beta-adrenergic-sensitive adenylate cyclase in secretory cells of choroid plexus.脉络丛分泌细胞中的β-肾上腺素能敏感腺苷酸环化酶。
Science. 1979 May 25;204(4395):843-4. doi: 10.1126/science.220707.
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beta-Adrenergic-sensitive adenylate cyclase in choroid plexus: properties and cellular localization.脉络丛中β-肾上腺素能敏感腺苷酸环化酶:特性与细胞定位
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Adrenergic regulation of intraocular pressure: identification of beta 2-adrenergic-stimulated adenylate cyclase in ciliary process epithelium.眼内压的肾上腺素能调节:睫状体上皮细胞中β2-肾上腺素能刺激的腺苷酸环化酶的鉴定。
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Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors.进一步的证据表明,β-肾上腺素能敏感腺苷酸环化酶的脱敏过程分两步进行。偶联的改变和β-肾上腺素能受体的丧失。
J Biol Chem. 1980 Nov 10;255(21):10436-44.

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Catecholaminergic and serotoninergic fibres innervate the ventricular system of the hedgehog CNS.儿茶酚胺能和5-羟色胺能纤维支配刺猬中枢神经系统的脑室系统。
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