Mcl-1 levels need not be lowered for cells to be sensitized for ABT-263/737-induced apoptosis.
作者信息
Yamaguchi R, Perkins G
出版信息
Cell Death Dis. 2011 Nov 10;2(11):e227. doi: 10.1038/cddis.2011.109.
Abstract
摘要
相似文献
1
Mcl-1 levels need not be lowered for cells to be sensitized for ABT-263/737-induced apoptosis.
Cell Death Dis. 2011 Nov 10;2(11):e227. doi: 10.1038/cddis.2011.109.
2
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
Blood. 2012 Jun 14;119(24):5807-16. doi: 10.1182/blood-2011-12-400929. Epub 2012 Apr 26.
3
Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737.
Mol Cancer Ther. 2009 Apr;8(4):883-92. doi: 10.1158/1535-7163.MCT-08-1118.
4
Glycolysis inhibition targets Mcl-1 to restore sensitivity of lymphoma cells to ABT-737-induced apoptosis.
Leukemia. 2012 May;26(5):1145-7. doi: 10.1038/leu.2011.327. Epub 2011 Nov 11.
5
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.
Cancer Res. 2007 Feb 1;67(3):1176-83. doi: 10.1158/0008-5472.CAN-06-2203.
6
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.
Cancer Res. 2007 Jan 15;67(2):782-91. doi: 10.1158/0008-5472.CAN-06-3964.
7
Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy.
PLoS One. 2011;6(9):e24102. doi: 10.1371/journal.pone.0024102. Epub 2011 Sep 19.
8
ABT-737 induces apoptosis in mantle cell lymphoma cells with a Bcl-2high/Mcl-1low profile and synergizes with other antineoplastic agents.
Clin Cancer Res. 2011 Sep 15;17(18):5973-81. doi: 10.1158/1078-0432.CCR-11-0955. Epub 2011 Aug 5.
9
Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer.
Int J Cancer. 2007 Dec 1;121(11):2387-94. doi: 10.1002/ijc.22977.
10
Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer.
Cell Death Dis. 2014 Feb 13;5(2):e1052. doi: 10.1038/cddis.2014.6.
引用本文的文献
1
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent Activities in Mouse Models of Hematological and Solid Tumors.
J Med Chem. 2024 Aug 22;67(16):14370-14393. doi: 10.1021/acs.jmedchem.4c01188. Epub 2024 Aug 5.
2
Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins.
Cancers (Basel). 2022 Mar 27;14(7):1706. doi: 10.3390/cancers14071706.
3
Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax.
Neurooncol Adv. 2021 Oct 8;3(1):vdab148. doi: 10.1093/noajnl/vdab148. eCollection 2021 Jan-Dec.
4
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
Drug Des Devel Ther. 2021 Jan 6;15:1-8. doi: 10.2147/DDDT.S286373. eCollection 2021.
5
BCL-2 family isoforms in apoptosis and cancer.
Cell Death Dis. 2019 Feb 21;10(3):177. doi: 10.1038/s41419-019-1407-6.
6
Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells.
Mol Cancer Res. 2015 Apr;13(4):659-69. doi: 10.1158/1541-7786.MCR-14-0476. Epub 2014 Dec 29.
7
Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts.
Clin Cancer Res. 2014 Sep 1;20(17):4520-31. doi: 10.1158/1078-0432.CCR-14-0259. Epub 2014 Jul 10.
8
Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors.
Commun Integr Biol. 2012 Nov 1;5(6):557-65. doi: 10.4161/cib.21554.
本文引用的文献
1
Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy.
PLoS One. 2011;6(9):e24102. doi: 10.1371/journal.pone.0024102. Epub 2011 Sep 19.
2
Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
Cancer Res. 2011 Aug 1;71(15):5204-13. doi: 10.1158/0008-5472.CAN-10-4531. Epub 2011 Jun 13.
3
Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells.
Cell Death Differ. 2010 Aug;17(8):1335-44. doi: 10.1038/cdd.2010.21. Epub 2010 Mar 5.
4
Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.
Oncogene. 2010 Mar 18;29(11):1641-52. doi: 10.1038/onc.2009.448. Epub 2009 Dec 7.
5
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289.
6
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
Cancer Cell. 2006 Nov;10(5):389-99. doi: 10.1016/j.ccr.2006.08.027.
7
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.
Cancer Cell. 2006 Nov;10(5):375-88. doi: 10.1016/j.ccr.2006.10.006.
8
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
Mol Cell. 2005 Feb 4;17(3):393-403. doi: 10.1016/j.molcel.2004.12.030.
Zotero 插件