Colin J, Chastel C
Sem Hop. 1978;54(33-36):1071-2.
The authors report two cases of severe herpetic keratitis and briefly discuss the possible mechanism of acquired idoxuridine resistance of herpes simplex virus. They believe that acquired resistance to IDU may be due to the treatment itself because of activity site of the inhibitor, i.e. the viral DNA.
作者报告了两例严重的疱疹性角膜炎病例,并简要讨论了单纯疱疹病毒获得性碘苷耐药的可能机制。他们认为,由于抑制剂的作用位点即病毒DNA,对碘苷的获得性耐药可能是由治疗本身导致的。