Charef S, Jozefowicz M, Labarre D, Tapon-Bretaudiere J, Fischer A M, Bros A
Laboratoire de Recherches sur les Macromolécules, CNRS UA 502, Université Paris-Nord, Villetaneuse, France.
Biomaterials. 1990 Aug;11(6):425-9. doi: 10.1016/0142-9612(90)90099-c.
Antithrombogenic functional polymer surfaces have been obtained by grafting heparin or by substituting insoluble polystyrene with sulphonate and/or amino acid sulphamide groups. Their heparin-like properties have been related to their catalytic effects on the antithrombin III - thrombin complex formation. Amongst these antithrombogenic surfaces, this study demonstrates that some insoluble amino acid sulphamide derivatives of polystyrene strongly potentiate heparin cofactor II, in addition to antithrombin III. In contrast, an insoluble polystyrene sulphonate and, to a lesser extent, an insoluble heparin copolymer, are better catalysts of antithrombin III. It is hypothesized that such different behaviours result from different conformations of the species adsorbed onto the surfaces. The conclusions support the possible use of such amino acid sulphamide groups to prepare antithrombogenic surfaces in contact with blood.
通过接枝肝素或用磺酸酯和/或氨基酸磺酰胺基团取代不溶性聚苯乙烯，已获得抗血栓形成功能聚合物表面。它们的类肝素特性与其对抗凝血酶III - 凝血酶复合物形成的催化作用有关。在这些抗血栓形成表面中，本研究表明，除了抗凝血酶III之外，一些不溶性聚苯乙烯氨基酸磺酰胺衍生物还能强烈增强肝素辅因子II的作用。相比之下，不溶性聚苯乙烯磺酸盐以及程度较轻的不溶性肝素共聚物是抗凝血酶III的更好催化剂。据推测，这种不同的行为是由吸附在表面上的物质的不同构象导致的。这些结论支持了使用此类氨基酸磺酰胺基团制备与血液接触的抗血栓形成表面的可能性。
