通过形成非外消旋的铵烯醇盐对 N,N-二烷基-L-氨基酸酯进行不对称的 α-2-对甲苯亚磺酰基烯基化反应。
Asymmetric α-2-tosylethenylation of N,N-dialkyl-L-amino acid esters via the formation of non-racemic ammonium enolates.
机构信息
Department of Chemistry, Faculty of Science, Niigata University, Niigata, 950-2181, Japan.
出版信息
Org Biomol Chem. 2012 Jan 14;10(2):339-45. doi: 10.1039/c1ob06074k. Epub 2011 Nov 10.
PMID:22072332
Abstract
Asymmetric α-2-tosylethenylation of (S)-2-(pyrrolidin-1-yl)propanoic acid esters was shown to produce good yields with high enantioselectivities. The reaction proceeds via the formation of a non-racemic ammonium enolate without an external source of chirality.
摘要
(S)-2-(吡咯烷-1-基)丙酸酯的不对称 α-2-对甲苯亚磺酰基烯丙基化反应以高产率和高对映选择性得到产物。该反应通过形成非外消旋的铵烯醇盐而无需外部手性源进行。
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