通过铵叶立德加成到芳醛上形成新型C-C键：一种构建β-芳基-β-羟基α-氨基酸骨架的简便方法。
Novel C-C bond formation through addition of ammonium ylides to arylaldehydes: a facile approach to beta-aryl-beta-hydroxy alpha-amino acid frameworks.
作者信息
Wang Yuanhua, Chen Zhiyong, Mi Aiqiao, Hu Wenhao
机构信息
Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Orangic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
出版信息
Chem Commun (Camb). 2004 Nov 7(21):2486-7. doi: 10.1039/b407449a. Epub 2004 Sep 14.
DOI:10.1039/b407449a
PMID:15514828
Abstract
Ammonium ylides generated in situ from [small alpha]-diazo esters and amines in the presence of catalytic Rh2(OAc)4, undergo an aldol-type reaction with aldehydes affording highly substituted amino acid frameworks in a convergent, three-component reaction.
摘要
由α-重氮酯和胺在催化量的Rh2(OAc)4存在下原位生成的叶立德铵，与醛发生羟醛型反应，通过一个汇聚性的三组分反应得到高度取代的氨基酸骨架。
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