手性通过酯烯醇化物克莱森重排的氨基酸衍生物的不对称 α-芳基化。
Asymmetric α-arylation of amino acid derivatives by Clayden rearrangement of ester enolates via memory of chirality.
机构信息
Institute for Chemical Research, Kyoto University , Uji, Kyoto 611-0011, Japan.
出版信息
J Am Chem Soc. 2013 Sep 11;135(36):13294-7. doi: 10.1021/ja406653n. Epub 2013 Aug 27.
PMID:23957387
Abstract
A method for asymmetric α-arylation of amino acid derivatives has been developed. The arylation was performed by Clayden rearrangement of ester enolates via memory of chirality to give hydantoins with an aryl-substituted tetrasubstituted carbon with up to 99% ee.
摘要
发展了一种氨基酸衍生物的不对称α-芳基化方法。芳基化是通过酯烯醇化物的 Clayden 重排，通过手性记忆来进行的，得到了具有高达 99%ee 的手性的带有取代的芳基的四取代碳的海因衍生物。
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