异丙肾上腺素使心脏钾电流失活的新作用不受β和α肾上腺素能阻滞剂的阻断。
A novel action of isoproterenol to inactivate a cardiac K+ current is not blocked by beta and alpha adrenergic blockers.
作者信息
Tromba C, Cohen I S
机构信息
Department of Physiology and Biophysics, State University of New York, Stony Brook 11794.
出版信息
Biophys J. 1990 Sep;58(3):791-5. doi: 10.1016/S0006-3495(90)82422-X.
Abstract
The K+ current iKl sets the resting potential in cardiac cells. Here we report that isoproterenol (ISO), a prototypical beta agonist, increases inactivation of iKl. This action of ISO on iKl is mimicked by permeant analogues of cAMP but is not blocked by the beta blockers propranolol and pindolol or the alpha blockers prazosin or yohimbine. We suggest that this novel action of ISO may contribute to pacemaker activity in the Purkinje strand and be mediated through a class of receptors different from classical beta's or alpha's.
摘要
钾离子电流iKl决定了心脏细胞的静息电位。在此我们报告，典型的β激动剂异丙肾上腺素（ISO）可增加iKl的失活。ISO对iKl的这种作用可被cAMP的渗透性类似物模拟，但不受β阻滞剂普萘洛尔和吲哚洛尔或α阻滞剂哌唑嗪或育亨宾的阻断。我们认为，ISO的这种新作用可能有助于浦肯野纤维束中的起搏活动，并通过一类不同于经典β或α受体的受体介导。
相似文献
1
A novel action of isoproterenol to inactivate a cardiac K+ current is not blocked by beta and alpha adrenergic blockers.异丙肾上腺素使心脏钾电流失活的新作用不受β和α肾上腺素能阻滞剂的阻断。
Biophys J. 1990 Sep;58(3):791-5. doi: 10.1016/S0006-3495(90)82422-X.
2
Effect of alpha adrenergic agonists and blockers on Purkinje fiber transmembrane potentials and automaticity in the dog.α肾上腺素能激动剂和阻滞剂对犬浦肯野纤维跨膜电位及自律性的影响。
J Pharmacol Exp Ther. 1984 Dec;231(3):566-71.
3
Both beta-adrenergic receptor stimulation and cardiac tissue type have important roles in elucidating the functional effects of I(Ks) channel blockers in vitro.β-肾上腺素能受体刺激和心脏组织类型在阐明体外 I(Ks) 通道阻滞剂的功能效应方面都起着重要作用。
J Pharmacol Toxicol Methods. 2005 Mar-Apr;51(2):81-90. doi: 10.1016/j.vascn.2004.10.004.
4
Evaluation of alpha-adrenergic cardiac stimulation in anesthetized dogs: can this play a role in propranolol insensitive cardiostimulatory effects of celiprolol.麻醉犬体内α-肾上腺素能心脏刺激的评估：这是否在塞利洛尔对普萘洛尔不敏感的心脏刺激作用中发挥作用？
Res Commun Chem Pathol Pharmacol. 1986 Dec;54(3):339-54.
5
Contribution of Na(+)-Ca2+ exchange to stimulation of transient inward current by isoproterenol in rabbit cardiac Purkinje fibers.钠钙交换在异丙肾上腺素刺激兔心脏浦肯野纤维瞬时内向电流中的作用。
Circ Res. 1995 Apr;76(4):664-74. doi: 10.1161/01.res.76.4.664.
6
Enhancement by norepinephrine of automaticity in sheep cardiac Purkinje fibers exposed to hypoxic glucose-free Tyrode's solution: a role for alpha-adrenoceptors?
Circulation. 1986 Jan;73(1):180-8. doi: 10.1161/01.cir.73.1.180.
7
Pharmacological identification of the alpha-adrenergic receptor type which inhibits the beta-adrenergic activated adenylate cyclase system in cultured astrocytes.对培养星形胶质细胞中抑制β-肾上腺素能激活的腺苷酸环化酶系统的α-肾上腺素能受体类型进行药理学鉴定。
Glia. 1989;2(2):129-33. doi: 10.1002/glia.440020209.
8
The effects of isoprenaline and a new beta-sympathomimetic amine upon spontaneous activity, diastolic depolarization and plateau height in cardiac Purkinje fibres.异丙肾上腺素和一种新型β-拟交感胺对心脏浦肯野纤维自发活动、舒张期去极化及平台期高度的影响。
Br J Pharmacol. 1978 Jul;63(3):427-34. doi: 10.1111/j.1476-5381.1978.tb07794.x.
9
Beta-adrenoceptor agonists increase membrane K+ conductance in cardiac Purkinje fibres.
Nature. 1983;306(5944):691-3. doi: 10.1038/306691a0.
10
Developmental changes in the interactions of cholinergic and beta-adrenergic agonists on electrophysiologic properties of canine cardiac Purkinje fibers.
Pediatr Res. 1986 Jul;20(7):613-8. doi: 10.1203/00006450-198607000-00007.
引用本文的文献
1
Beta-Adrenergic Activation of the Inward Rectifier K Current Is Mediated by the CaMKII Pathway in Canine Ventricular Cardiomyocytes.β肾上腺素能激活内向整流钾电流是通过钙调蛋白依赖性激酶 II 通路介导的在犬心室心肌细胞。
Int J Mol Sci. 2024 Oct 29;25(21):11609. doi: 10.3390/ijms252111609.
2
Cardiac potassium inward rectifier Kir2: Review of structure, regulation, pharmacology, and arrhythmogenesis.心脏钾离子内向整流通道 Kir2：结构、调节、药理学和心律失常发生机制的综述。
Heart Rhythm. 2021 Aug;18(8):1423-1434. doi: 10.1016/j.hrthm.2021.04.008. Epub 2021 Apr 20.
3
Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling.调节心率和起博电流的磷酸肌醇 3-激酶信号转导。
J Gen Physiol. 2019 Aug 5;151(8):1051-1058. doi: 10.1085/jgp.201812293. Epub 2019 Jun 19.
4
Conduction in the right and left ventricle is differentially regulated by protein kinases and phosphatases: implications for arrhythmogenesis.蛋白激酶和磷酸酶对右心室和左心室的传导具有不同的调节作用：对心律失常发生机制的影响。
Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1507-H1527. doi: 10.1152/ajpheart.00660.2018. Epub 2019 Mar 15.
5
Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.心脏中的钾电流：在复极化、心律失常及治疗中的功能作用
J Physiol. 2017 Apr 1;595(7):2229-2252. doi: 10.1113/JP272883. Epub 2017 Jan 5.
6
Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potential.β-肾上腺素能刺激可逆转心脏动作电位期间I Kr-I Ks的主导模式。
Pflugers Arch. 2014 Nov;466(11):2067-76. doi: 10.1007/s00424-014-1465-7. Epub 2014 Feb 19.
7
Fractalkine Mediates Communication between Pathogenic Proteins and Microglia: Implications of Anti-Inflammatory Treatments in Different Stages of Neurodegenerative Diseases.fractalkine介导致病蛋白与小胶质细胞之间的通讯：抗炎治疗在神经退行性疾病不同阶段的意义
Int J Alzheimers Dis. 2012;2012:345472. doi: 10.1155/2012/345472. Epub 2012 Aug 5.
8
Protein kinase A-dependent biophysical phenotype for V227F-KCNJ2 mutation in catecholaminergic polymorphic ventricular tachycardia.儿茶酚胺能多形性室性心动过速中V227F-KCNJ2突变的蛋白激酶A依赖性生物物理表型。
Circ Arrhythm Electrophysiol. 2009 Oct;2(5):540-7. doi: 10.1161/CIRCEP.109.872309. Epub 2009 Aug 25.
9
H-89 inhibits transient outward and inward rectifier potassium currents in isolated rat ventricular myocytes.H-89抑制离体大鼠心室肌细胞的瞬时外向钾电流和内向整流钾电流。
Br J Pharmacol. 2006 Aug;148(8):1091-8. doi: 10.1038/sj.bjp.0706810. Epub 2006 Jun 26.
10
beta-Adrenergic modulation of the inwardly rectifying potassium channel in isolated human ventricular myocytes. Alteration in channel response to beta-adrenergic stimulation in failing human hearts.离体人心室肌细胞内向整流钾通道的β-肾上腺素能调节。衰竭人心脏中通道对β-肾上腺素能刺激反应的改变。
J Clin Invest. 1995 Dec;96(6):2870-81. doi: 10.1172/JCI118358.
本文引用的文献
1
Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs.棕色脂肪细胞上的非典型β-肾上腺素能受体作为抗肥胖药物的靶点。
Nature. 1984;309(5964):163-5. doi: 10.1038/309163a0.
2
Effect of alpha adrenergic agonists and blockers on Purkinje fiber transmembrane potentials and automaticity in the dog.α肾上腺素能激动剂和阻滞剂对犬浦肯野纤维跨膜电位及自律性的影响。
J Pharmacol Exp Ther. 1984 Dec;231(3):566-71.
3
Beta-adrenoceptor agonists increase membrane K+ conductance in cardiac Purkinje fibres.
Nature. 1983;306(5944):691-3. doi: 10.1038/306691a0.
4
Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization.腺苷酸环化酶偶联的β-肾上腺素能受体：激活与脱敏的结构及机制
Annu Rev Biochem. 1983;52:159-86. doi: 10.1146/annurev.bi.52.070183.001111.
5
Interactions of agonists with platelet alpha 2-adrenergic receptors.激动剂与血小板α2 - 肾上腺素能受体的相互作用。
Endocrinology. 1982 Mar;110(3):926-32. doi: 10.1210/endo-110-3-926.
6
Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation.吲哚洛尔光学异构体对豚鼠窦房结和气管的兴奋及阻断作用。β-肾上腺素能受体亚型在阻断与兴奋解离中的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep;327(2):159-75. doi: 10.1007/BF00500912.
7
Beta-adrenergic increase in the calcium conductance of cardiac myocytes studied with the patch clamp.用膜片钳技术研究β-肾上腺素能对心肌细胞钙电导的影响。
Pflugers Arch. 1984 Jun;401(2):111-8. doi: 10.1007/BF00583870.
8
Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons.四乙铵离子衍生物与巨轴突钾通道的相互作用。
J Gen Physiol. 1971 Oct;58(4):413-37. doi: 10.1085/jgp.58.4.413.
9
The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.利多卡因季铵衍生物对有髓神经中钠电流的抑制作用。
J Gen Physiol. 1973 Jul;62(1):37-57. doi: 10.1085/jgp.62.1.37.
10
Effects of epinephrine on the pacemaker potassium current of cardiac Purkinje fibers.肾上腺素对心脏浦肯野纤维起搏钾电流的影响。
J Gen Physiol. 1974 Sep;64(3):293-319. doi: 10.1085/jgp.64.3.293.
Zotero 插件