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Proof of principle for crizotinib in anaplastic lymphoma kinase-positive malignancies was achieved in ALK-positive nonclinical models.

作者信息

Christensen James G

机构信息

Pfizer Global Research and Development, Precision Medicine, La Jolla, San Diego, CA 92121, USA.

出版信息

Mol Cancer Ther. 2011 Nov;10(11):2024. doi: 10.1158/1535-7163.MCT-11-0721.

DOI:10.1158/1535-7163.MCT-11-0721
PMID:22072808
Abstract
摘要

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Proof of principle for crizotinib in anaplastic lymphoma kinase-positive malignancies was achieved in ALK-positive nonclinical models.在间变性淋巴瘤激酶阳性恶性肿瘤中，克唑替尼的原理验证在ALK阳性非临床模型中得以实现。
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Crizotinib, a small-molecule dual inhibitor of the c-Met and ALK receptor tyrosine kinases.克唑替尼，一种c-Met和ALK受体酪氨酸激酶的小分子双重抑制剂。
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Biomedicines. 2024 Sep 4;12(9):2021. doi: 10.3390/biomedicines12092021.
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Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma.克唑替尼在神经母细胞瘤临床前模型中与化疗协同作用。
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Setting up a wide panel of patient-derived tumor xenografts of non-small cell lung cancer by improving the preanalytical steps.
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Cancer Med. 2015 Feb;4(2):201-11. doi: 10.1002/cam4.357. Epub 2014 Dec 3.
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Contrast agents for quantitative microCT of lung tumors in mice.用于小鼠肺部肿瘤定量显微CT的造影剂。
Comp Med. 2013;63(6):482-90.
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Potential therapies for anaplastic lymphoma kinase-driven tumors in children: progress to date.儿童间变性淋巴瘤激酶驱动肿瘤的潜在治疗方法：最新进展。
Paediatr Drugs. 2013 Jun;15(3):163-9. doi: 10.1007/s40272-013-0027-3.
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Patient-derived tumour xenografts as models for oncology drug development.患者来源肿瘤异种移植模型在肿瘤药物开发中的应用。
Nat Rev Clin Oncol. 2012 Apr 17;9(6):338-50. doi: 10.1038/nrclinonc.2012.61.