• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

药物遗传学在过敏性疾病和哮喘治疗中的影响。

The impact of pharmacogenetics in the treatment of allergic disease and asthma.

作者信息

Jones Bridgette L

机构信息

Department of Pediatrics, Children's Mercy Hospital and Clinics, USA.

出版信息

Mo Med. 2011 Sep-Oct;108(5):361-5.

PMID:22073496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6188382/
Abstract

Personalized medicine includes the application of genomic information in predicting disease and therapeutic response to ultimately individualize patient care. Pharmacogenetics is key in achieving true personalized care. However, the clinical applicability of genetic testing to "everyday medicine" is yet to be realized. This paper will discuss areas in allergic/inflammatory disease that have been impacted by pharmacogenetic research and how this application may be brought from the "bench to the bedside."

摘要

个性化医疗包括应用基因组信息来预测疾病和治疗反应,最终实现患者护理的个体化。药物遗传学是实现真正个性化护理的关键。然而,基因检测在“日常医疗”中的临床适用性尚未实现。本文将讨论药物遗传学研究对过敏性/炎症性疾病领域的影响,以及如何将这种应用从“实验室带到临床”。

相似文献

1
The impact of pharmacogenetics in the treatment of allergic disease and asthma.药物遗传学在过敏性疾病和哮喘治疗中的影响。
Mo Med. 2011 Sep-Oct;108(5):361-5.
2
The pharmacogenetics of asthma treatment.哮喘治疗的药物遗传学
Curr Allergy Asthma Rep. 2009 Jan;9(1):10-7. doi: 10.1007/s11882-009-0002-9.
3
The pharmacogenetics and pharmacogenomics of asthma therapy.哮喘治疗的药物遗传学和药物基因组学。
Pharmacogenomics J. 2011 Dec;11(6):383-92. doi: 10.1038/tpj.2011.46. Epub 2011 Oct 11.
4
Genetics and the variability of treatment response in asthma.遗传学与哮喘治疗反应的变异性
J Allergy Clin Immunol. 2005 Apr;115(4 Suppl):S532-8. doi: 10.1016/j.jaci.2005.01.029.
5
[Molecular and pharmacogenetic mechanisms of severe asthma].[重症哮喘的分子与药物遗传学机制]
Vestn Ross Akad Med Nauk. 2013(3):15-23. doi: 10.15690/vramn.v68i3.596.
6
[Treatment of asthma; are there still questions?].
Ned Tijdschr Geneeskd. 1996 Jan 13;140(2):72-7.
7
Review on Pharmacogenetics and Pharmacogenomics Applied to the Study of Asthma.应用于哮喘研究的药物遗传学与药物基因组学综述
Methods Mol Biol. 2016;1434:255-72. doi: 10.1007/978-1-4939-3652-6_18.
8
Pharmacogenetics of anti-inflammatory treatment in children with asthma: rationale and design of the PACMAN cohort.儿童哮喘抗炎治疗的药物遗传学:PACMAN 队列的原理和设计。
Pharmacogenomics. 2009 Aug;10(8):1351-61. doi: 10.2217/pgs.09.79.
9
Treatment of acute asthma.急性哮喘的治疗
Lancet. 1997 Oct;350 Suppl 2:SII18-23. doi: 10.1016/s0140-6736(97)90032-5.
10
Genetics, ethics, and the use of long-acting beta-adrenergics to treat asthma.遗传学、伦理学以及长效β-肾上腺素能药物在哮喘治疗中的应用
Am J Respir Crit Care Med. 2010 Apr 1;181(7):647-8. doi: 10.1164/rccm.200912-1890ED.

引用本文的文献

1
Pharmacogenetics of childhood uncontrolled asthma.儿童难治性哮喘的药物遗传学
Expert Rev Clin Immunol. 2025 Feb;21(2):181-194. doi: 10.1080/1744666X.2023.2214363. Epub 2023 May 19.

本文引用的文献

1
Warfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness study).华法林基因分型降低了住院率,这是 MM-WES(美科梅奥华法林有效性研究)的结果。
J Am Coll Cardiol. 2010 Jun 22;55(25):2804-12. doi: 10.1016/j.jacc.2010.03.009. Epub 2010 Apr 8.
2
Polymorphism of the ADRB2 gene and response to inhaled beta- agonists in children with asthma: a meta-analysis.ADRB2基因多态性与哮喘儿童吸入β受体激动剂的反应:一项荟萃分析。
J Asthma. 2009 Nov;46(9):900-5. doi: 10.3109/02770900903199961.
3
Pharmacogenomics, evidence, and the role of payers.药物基因组学、证据及支付方的作用。
Public Health Genomics. 2009;12(3):149-57. doi: 10.1159/000189627. Epub 2009 Feb 10.
4
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts.精氨酸酶1是一种新型支气管扩张反应基因:在四个哮喘队列中的筛选与验证
Am J Respir Crit Care Med. 2008 Oct 1;178(7):688-94. doi: 10.1164/rccm.200709-1363OC. Epub 2008 Jul 10.
5
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.5-脂氧合酶(ALOX5)启动子基因型与中度持续性哮喘患者对孟鲁司特的反应
Respir Med. 2008 Jun;102(6):857-61. doi: 10.1016/j.rmed.2008.01.011. Epub 2008 Mar 12.
6
HLA-B*5701 screening for hypersensitivity to abacavir.进行HLA-B*5701筛查以检测对阿巴卡韦的超敏反应。
N Engl J Med. 2008 Feb 7;358(6):568-79. doi: 10.1056/NEJMoa0706135.
7
Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies.β2肾上腺素能受体基因多态性对长效β2激动剂治疗反应的影响:两项随机研究的药物遗传学分析
Lancet. 2007 Dec 22;370(9605):2118-25. doi: 10.1016/S0140-6736(07)61906-0.
8
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.汉族人群中HLA - B*1502等位基因与抗癫痫药物所致皮肤反应之间的关联
Epilepsia. 2007 May;48(5):1015-8. doi: 10.1111/j.1528-1167.2007.01022.x.
9
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol.沙美特罗多中心哮喘研究试验:哮喘常规药物治疗与常规药物治疗加沙美特罗的比较。
Chest. 2006 Jan;129(1):15-26. doi: 10.1378/chest.129.1.15.
10
beta-Adrenergic receptor polymorphisms and response to salmeterol.β-肾上腺素能受体基因多态性与沙美特罗反应
Am J Respir Crit Care Med. 2006 Mar 1;173(5):519-26. doi: 10.1164/rccm.200509-1519OC. Epub 2005 Dec 1.