多巴胺能刺激分散的牛甲状旁腺细胞中环磷酸腺苷的积累和甲状旁腺激素的释放。
Dopaminergic stimulation of cyclic AMP accumulation and parathyroid hormone release from dispersed bovine parathyroid cells.
作者信息
Brown E M, Carroll R J, Aurbach G D
出版信息
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4210-3. doi: 10.1073/pnas.74.10.4210.
Abstract
The effects of dopaminergic agonists and antagonists have been studied in dispersed bovine parathyroid cells. Dopaminergic agonists caused a transient 20- to 40-fold increase in cellular cyclic AMP and a 2- to 3-fold increase in parathyroid hormone release. Dose-response relationships were similar for cyclic AMP accumulation and hormone release, whether studied by increasing agonist concentration or by increasing concentration of antagonist with constant agonist. The effects on the dopamine receptor could be differentiated from those of the previously characterized beta-adrenergic receptor by specific inhibitors. These results appear to represent proof with a homogeneous cell population that dopaminergic receptors linked to adenylate cyclase can regulate a secretory process mediated by cyclic AMP. This system should be useful in further studies on dopamine receptors and should provide a valid tool for determining interactions of radiolabeled ligands with such receptors.
摘要
已在分散的牛甲状旁腺细胞中研究了多巴胺能激动剂和拮抗剂的作用。多巴胺能激动剂使细胞内环磷酸腺苷（cAMP）瞬时增加20至40倍，甲状旁腺激素释放增加2至3倍。无论通过增加激动剂浓度还是通过在恒定激动剂浓度下增加拮抗剂浓度来研究，cAMP积累和激素释放的剂量反应关系都是相似的。通过特异性抑制剂，可将对多巴胺受体的作用与先前鉴定的β-肾上腺素能受体的作用区分开来。这些结果似乎证明，在同质细胞群体中，与腺苷酸环化酶相连的多巴胺能受体可调节由cAMP介导的分泌过程。该系统应有助于进一步研究多巴胺受体，并应为确定放射性标记配体与此类受体的相互作用提供一个有效的工具。
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