多巴胺对视网膜匀浆中腺苷酸环化酶的刺激作用以及对完整视网膜中3':5'-环磷酸腺苷形成的刺激作用。
Stimulation by dopamine of adenylate cyclase in retinal homogenates and of adenosine-3':5'-cyclic monophosphate formation in intact retina.
作者信息
Brown J H, Makman M H
出版信息
Proc Natl Acad Sci U S A. 1972 Mar;69(3):539-43. doi: 10.1073/pnas.69.3.539.
Abstract
A catecholamine-sensitive adenylate cyclase system is present in homogenates of both calf and rat retinas. Dopamine is a more potent activator of the bovine enzyme than is norepinephrine or epinephrine. Cyclic AMP concentrations in intact bovine retina are increased by dopamine, as well as by other catecholamines, and by depolarizing agents. Studies with adrenergic blocking agents suggest that the stimulation of retinal adenylate cyclase by catecholamines cannot be clearly defined in terms of the characteristics of alpha or beta adrenergic receptors. Bovine retina also contains a protein kinase that is stimulated 20-fold by cyclic AMP. It is proposed that dopamine is the major activator of a retinal adenylate cyclase, and that this activation is related to its role as a neurotransmitter.
摘要
牛和大鼠视网膜的匀浆中都存在一种对儿茶酚胺敏感的腺苷酸环化酶系统。多巴胺对牛酶的激活作用比去甲肾上腺素或肾上腺素更强。多巴胺以及其他儿茶酚胺和去极化剂均可使完整牛视网膜中的环磷酸腺苷（cAMP）浓度升高。使用肾上腺素能阻滞剂的研究表明，根据α或β肾上腺素能受体的特性，无法明确儿茶酚胺对视网膜腺苷酸环化酶的刺激作用。牛视网膜还含有一种蛋白激酶，它可被环磷酸腺苷激活20倍。有人提出，多巴胺是视网膜腺苷酸环化酶的主要激活剂，这种激活作用与其作为神经递质的作用有关。
相似文献
1
Stimulation by dopamine of adenylate cyclase in retinal homogenates and of adenosine-3':5'-cyclic monophosphate formation in intact retina.多巴胺对视网膜匀浆中腺苷酸环化酶的刺激作用以及对完整视网膜中3':5'-环磷酸腺苷形成的刺激作用。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):539-43. doi: 10.1073/pnas.69.3.539.
2
Effect of adrenergic agents on alpha-amylase release and adenosine 3',5'-monophosphate accumulation in rat parotid tissue slices.肾上腺素能药物对大鼠腮腺组织切片中α-淀粉酶释放及3',5'-环磷酸腺苷积累的影响。
Biochim Biophys Acta. 1975 May 5;392(1):82-94. doi: 10.1016/0304-4165(75)90168-3.
3
Catecholamine-sensitive adenylate cyclase in the white perch (Roccus americanus) retina: evidence for beta-adrenergic and dopamine receptors linked to adenylate cyclase.白鲈（美洲犬牙石首鱼）视网膜中对儿茶酚胺敏感的腺苷酸环化酶：与腺苷酸环化酶相连的β-肾上腺素能受体和多巴胺受体的证据
J Neurochem. 1989 Sep;53(3):969-75. doi: 10.1111/j.1471-4159.1989.tb11801.x.
4
Epinephrine and norepinephrine stimulation of adenylate cyclase in bovine retina homogenate: evidence for interaction with the dopamine D1 receptor.肾上腺素和去甲肾上腺素对牛视网膜匀浆中腺苷酸环化酶的刺激作用：与多巴胺D1受体相互作用的证据。
Life Sci. 1986 Mar 31;38(13):1221-7. doi: 10.1016/0024-3205(86)90177-3.
5
Dopamine- and apomorphine-sensitive adenylate cyclase in homogenates of rabbit retina.兔视网膜匀浆中对多巴胺和阿扑吗啡敏感的腺苷酸环化酶
Naunyn Schmiedebergs Arch Pharmacol. 1975;288(1):103-7. doi: 10.1007/BF00501818.
6
Dopaminergic mechanisms in the teleost retina. I. Dopamine-sensitive adenylate cyclase in homogenates of carp retina; effects of agonists, antagonists, and ergots.硬骨鱼视网膜中的多巴胺能机制。I. 鲤鱼视网膜匀浆中的多巴胺敏感腺苷酸环化酶；激动剂、拮抗剂和麦角碱的作用。
J Neurochem. 1981 Feb;36(2):559-68. doi: 10.1111/j.1471-4159.1981.tb01628.x.
7
Demonstration of dopamine-sensitive adenylate cyclase in malignant neuroblastoma cells and change in sensitivity of adenylate cyclase to catecholamines in "differentiated" cells.恶性神经母细胞瘤细胞中多巴胺敏感性腺苷酸环化酶的证实以及“分化”细胞中腺苷酸环化酶对儿茶酚胺敏感性的变化。
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2525-9. doi: 10.1073/pnas.71.6.2525.
8
Dopamine-sensitive adenylate cyclase in the rat kidney particulate preparation.大鼠肾脏微粒体制剂中的多巴胺敏感腺苷酸环化酶
Eur J Pharmacol. 1977 Jan 21;41(2):163-9. doi: 10.1016/0014-2999(77)90205-9.
9
Characteristics of dopamine and beta-adrenergic sensitive adenylate cyclases in the frontal cerebral cortex of the rat. Comparative effects of neuroleptics on frontal cortex and striatal dopamine sensitive adenylate cyclases.大鼠额叶大脑皮质中多巴胺和β-肾上腺素能敏感腺苷酸环化酶的特性。抗精神病药物对额叶皮质和纹状体多巴胺敏感腺苷酸环化酶的比较作用。
Brain Res. 1977 Feb 11;122(1):71-86. doi: 10.1016/0006-8993(77)90663-1.
10
Effect of adrenergic stimulation on adenylate cyclase activity in rat prostate.肾上腺素能刺激对大鼠前列腺腺苷酸环化酶活性的影响。
Biochim Biophys Acta. 1980 Mar 20;628(3):255-62. doi: 10.1016/0304-4165(80)90374-8.
引用本文的文献
1
Unveiling the Differences in Signaling and Regulatory Mechanisms between Dopamine D and D Receptors and Their Impact on Behavioral Sensitization.揭示多巴胺 D 和 D 受体在信号转导和调节机制方面的差异及其对行为敏化的影响。
Int J Mol Sci. 2023 Apr 4;24(7):6742. doi: 10.3390/ijms24076742.
2
Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development.神经递质、神经肽与钙在卵母细胞成熟和早期发育中的作用
Front Cell Dev Biol. 2022 Sep 23;10:980219. doi: 10.3389/fcell.2022.980219. eCollection 2022.
3
Allosteric Modulators of G Protein-Coupled Dopamine and Serotonin Receptors: A New Class of Atypical Antipsychotics.G蛋白偶联多巴胺和5-羟色胺受体的变构调节剂：一类新型非典型抗精神病药物。
Pharmaceuticals (Basel). 2020 Nov 14;13(11):388. doi: 10.3390/ph13110388.
4
Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson's disease.多巴胺受体的生理和功能基础及其在神经发生中的作用：对帕金森病的潜在影响
J Exp Neurosci. 2018 May 31;12:1179069518779829. doi: 10.1177/1179069518779829. eCollection 2018.
5
You are what you eat: influence of type and amount of food consumed on central dopamine systems and the behavioral effects of direct- and indirect-acting dopamine receptor agonists.你吃什么就是什么：所摄入食物的类型和数量对中枢多巴胺系统的影响，以及直接和间接作用的多巴胺受体激动剂的行为效应。
Neuropharmacology. 2012 Jul;63(1):76-86. doi: 10.1016/j.neuropharm.2012.02.005. Epub 2012 Feb 23.
6
Inhibition of adult rat retinal ganglion cells by D1-type dopamine receptor activation.D1 型多巴胺受体激活对成年大鼠视网膜神经节细胞的抑制作用。
J Neurosci. 2009 Nov 25;29(47):15001-16. doi: 10.1523/JNEUROSCI.3827-09.2009.
7
The novel distribution of phosphodiesterase-4 subtypes within the rat retina.大鼠视网膜内磷酸二酯酶-4 亚型的新分布。
Neuroscience. 2009 Nov 10;163(4):1277-91. doi: 10.1016/j.neuroscience.2009.07.045. Epub 2009 Jul 26.
8
A dopamine- and protein kinase A-dependent mechanism for network adaptation in retinal ganglion cells.视网膜神经节细胞中一种依赖多巴胺和蛋白激酶A的网络适应机制。
J Neurosci. 2001 Nov 1;21(21):8624-35. doi: 10.1523/JNEUROSCI.21-21-08624.2001.
9
Dopamine receptor localization in the mammalian retina.多巴胺受体在哺乳动物视网膜中的定位。
Mol Neurobiol. 1999 Jun;19(3):181-204. doi: 10.1007/BF02821713.
10
Guanine nucleotides do not inhibit tritiated dopamine agonist binding to bovine striatal membranes.鸟嘌呤核苷酸不抑制氚化多巴胺激动剂与牛纹状体膜的结合。
Neurochem Res. 1982 Jul;7(7):831-7. doi: 10.1007/BF00965676.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
IDENTIFICATION AND CELLULAR LOCALIZATION OF THE CATECHOLAMINES IN THE RETINA AND THE CHOROID OF THE RABBIT.兔视网膜和脉络膜中儿茶酚胺的鉴定及细胞定位
Acta Physiol Scand. 1965 May-Jun;64:58-66. doi: 10.1111/j.1748-1716.1965.tb04153.x.
3
The influence of light and dark on the catecholamine content of the retina and choroid.光与暗对视网膜和脉络膜儿茶酚胺含量的影响。
Invest Ophthalmol. 1967 Dec;6(6):642-6.
4
Correspondence between glutamine synthetase activity and differentiation in the embryonic retina in situ and in cultrue.胚胎视网膜原位及培养中谷氨酰胺合成酶活性与分化之间的对应关系。
J Cell Biol. 1965 Oct;27(1):247-52. doi: 10.1083/jcb.27.1.247.
5
The role of biogenic amines in the extra-pyramidal system.生物胺在锥体外系中的作用。
Acta Physiol Pharmacol Neerl. 1969 Jun;15(2):141-54.
6
Hormonal effects on the neural retina. I. Glutamine synthetase development in the retina and liver of the normal and triiodothyronine-treated rat.
Arch Biochem Biophys. 1971 Jun;144(2):657-62. doi: 10.1016/0003-9861(71)90372-9.
7
8
Receptor activity and turnover of dopamine and noradrenaline after neuroleptics.抗精神病药物治疗后多巴胺和去甲肾上腺素的受体活性及更新率
Eur J Pharmacol. 1970;11(3):303-14. doi: 10.1016/0014-2999(70)90006-3.
9
The inhibition of retinal ganglion cells by catecholeamines and gamma-aminobutyric acid.儿茶酚胺和γ-氨基丁酸对视网膜神经节细胞的抑制作用。
Pflugers Arch. 1969;312(3):45-54. doi: 10.1007/BF00588530.
Zotero 插件