Li Peng, An Lin, Reif Roberto, Shen Tueng T, Johnstone Murray, Wang Ruikang K
Biomed Opt Express. 2011 Nov 1;2(11):3109-18. doi: 10.1364/BOE.2.003109. Epub 2011 Oct 18.
The corneo-scleral limbus contains several biological components, which are important constituents for understanding, diagnosing and managing several ocular pathologies, such as glaucoma and corneal abnormalities. An anterior segment optical coherence tomography (AS-OCT) system integrated with optical microangiography (OMAG) is used in this study to non-invasively visualize the three-dimensional microstructural and microvascular properties of the limbal region. Advantages include first the ability to correct optical distortion of microstructural images enabling quantification of relationships in the anterior chamber angle. Second, microvascular images enable the visualization of the microcirculation in the limbal area without the use of exogenous contrast agents. Third, by combining the microstructural and microvascular information, the aqueous outflow pathway can be identified. The proposed AS-OCT can serve as a useful tool for ophthalmological research to determine normal and pathologic changes in the outflow system. As a clinical tool it has the potential to detect early aqueous outflow system abnormalities that lead to the pressure elevation in glaucoma. Recent surgical innovations and their implementations also rely on an assessment of outflow system structure and function, which can be revealed by AS-OCT.
角膜缘包含多种生物学成分，这些成分是理解、诊断和管理多种眼部疾病（如青光眼和角膜异常）的重要组成部分。本研究使用了一种集成了光学微血管造影（OMAG）的眼前节光学相干断层扫描（AS-OCT）系统，以无创方式可视化角膜缘区域的三维微观结构和微血管特性。优点包括：第一，能够校正微观结构图像的光学畸变，从而能够量化前房角的关系。第二，微血管图像能够在不使用外源性造影剂的情况下可视化角膜缘区域的微循环。第三，通过结合微观结构和微血管信息，可以识别房水流出途径。所提出的AS-OCT可作为眼科研究的有用工具，以确定流出系统的正常和病理变化。作为一种临床工具，它有潜力检测导致青光眼眼压升高的早期房水流出系统异常。最近的手术创新及其实施也依赖于对流出系统结构和功能的评估，而AS-OCT可以揭示这些信息。
