心脏 X 综合征患者血尿酸水平及其与颈动脉内膜中层厚度的关系。

Uric acid level and its association with carotid intima-media thickness in patients with cardiac syndrome X.

机构信息

Department of Cardiology, College of Medicine, Inonu University, Malatya, Turkey.

出版信息

Med Princ Pract. 2012;21(2):115-9. doi: 10.1159/000332583. Epub 2011 Nov 9.

DOI:10.1159/000332583

PMID:22076385

Abstract

OBJECTIVE

The aim of our study was to evaluate serum uric acid level and its relationship with carotid intima-media thickness (CIMT) in patients with cardiac syndrome X (CSX).

SUBJECTS AND METHODS

A total of 50 patients with CSX (28 females/22 males, 51.0 ± 10.9 years) and 40 controls (27 females/13 males, 53.0 ± 10.2 years) were included in the study. All subjects underwent a noninvasive stress test and conventional coronary angiography. Serum uric acid levels were measured and B mode ultrasonography was performed to assess CIMT in all subjects.

RESULTS

Serum uric acid levels were higher in patients with CSX than in the control subjects (5.1 ± 1.8 vs. 3.9 ± 1.3 mg/dl; p = 0.002). The CIMT was higher in patients with CSX than in the control subjects (0.75 ± 0.18 vs. 0.63 ± 0.09 mm; p < 0.001). A significant correlation was found between serum uric acid values and CIMT measurements in patients with CSX (r = 0.666, p < 0.001).

CONCLUSIONS

Serum uric acid levels were higher in patients with CSX and elevated serum uric acid levels were associated with carotid atherosclerosis, thereby indicating that elevated serum uric acid levels might contribute to the development of subclinical atherosclerosis in CSX patients.

摘要

目的

本研究旨在评估心脏 X 综合征（CSX）患者血清尿酸水平及其与颈动脉内膜中层厚度（CIMT）的关系。

受试者与方法

共纳入 50 例 CSX 患者（28 名女性/22 名男性，51.0±10.9 岁）和 40 名对照者（27 名女性/13 名男性，53.0±10.2 岁）。所有受试者均接受了非侵入性应激试验和常规冠状动脉造影。测量所有受试者的血清尿酸水平，并进行 B 型超声检查以评估 CIMT。

结果

CSX 患者的血清尿酸水平高于对照组（5.1±1.8 比 3.9±1.3mg/dl；p=0.002）。CSX 患者的 CIMT 高于对照组（0.75±0.18 比 0.63±0.09mm；p<0.001）。CSX 患者的血清尿酸值与 CIMT 测量值之间存在显著相关性（r=0.666，p<0.001）。