Opening the field of integrin biology to "biased agonism".
作者信息
Simon Daniel I
出版信息
Circ Res. 2011 Nov 11;109(11):1199-201. doi: 10.1161/CIRCRESAHA.111.257980.
Abstract
摘要
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本文引用的文献
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Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice.CD40L 与 Mac-1 的 I 结构域的结合涉及 EQLKKSKTL 基序，并介导白细胞募集和动脉粥样硬化 - 但不影响小鼠的免疫和血栓形成。
Circ Res. 2011 Nov 11;109(11):1269-79. doi: 10.1161/CIRCRESAHA.111.247684. Epub 2011 Oct 13.
2
Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury.巨噬细胞-1（CD11b/CD18）在肾小球损伤后将炎症与血栓形成联系起来。
Circulation. 2009 Sep 29;120(13):1255-65. doi: 10.1161/CIRCULATIONAHA.109.873695. Epub 2009 Sep 14.
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Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function.叉头转录因子Foxp1的下调是单核细胞分化和巨噬细胞功能所必需的。
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Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-kappaB activity.白细胞整合素Mac-1招募Toll/白细胞介素-1受体超家族信号中间体来调节核因子-κB活性。
Circ Res. 2001 Nov 9;89(10):859-65. doi: 10.1161/hh2201.099166.
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