Department of Psychiatry and Psychotherapy, Charité University Medicine Campus Mitte, Berlin, Germany.
Hum Brain Mapp. 2013 Feb;34(2):374-83. doi: 10.1002/hbm.21446. Epub 2011 Nov 11.
Trait impulsiveness is a potential factor that predicts both substance use and certain psychiatric disorders. This study investigates whether there are common structural cerebral correlates of trait impulsiveness and cognitive functioning in a large sample of healthy adolescents from the IMAGEN project.
Clusters of gray matter (GM) volume associated with trait impulsiveness, Cloningers' revised temperament, and character inventory impulsiveness (TCI-R-I) were identified in a whole brain analysis using optimized voxel-based morphometry in 115 healthy 14-year-olds. The clusters were tested for correlations with performance on the nonverbal tests (Block Design, BD; Matrix Reasoning, MT) of the Wechsler Scale of Intelligence for Children IV reflecting perceptual reasoning.
Cloningers' impulsiveness (TCI-R-I) score was significantly inversely associated with GM volume in left orbitofrontal cortex (OFC). Frontal clusters found were positively correlated with performance in perceptual reasoning tasks (Bonferroni corrected). No significant correlations between TCI-R-I and perceptual reasoning were observed.
The neural correlate of trait impulsiveness in the OFC matches an area where brain function has previously been related to inhibitory control. Additionally, orbitofrontal GM volume was associated with scores for perceptual reasoning. The data show for the first time structural correlates of both cognitive functioning and impulsiveness in healthy adolescent subjects.
特质冲动性是预测物质使用和某些精神障碍的潜在因素。本研究调查了在 IMAGEN 项目的一个大样本人群中，特质冲动性和认知功能是否存在共同的大脑结构相关性。
使用优化的基于体素的形态测量学，在 115 名健康的 14 岁青少年中进行全脑分析，确定与特质冲动性、Cloningers 修订的气质和性格冲动性量表（TCI-R-I）相关的灰质（GM）体积簇。对这些簇进行测试，以与反映知觉推理的韦氏儿童智力量表第四版的非言语测试（积木设计，BD；矩阵推理，MT）的表现相关。
Cloningers 的冲动性（TCI-R-I）得分与左眶额皮质（OFC）的 GM 体积呈显著负相关。发现的额叶簇与知觉推理任务的表现呈正相关（经 Bonferroni 校正）。TCI-R-I 与知觉推理之间没有显著相关性。
OFC 中的特质冲动性的神经相关性与大脑功能先前与抑制控制相关的区域相匹配。此外，眶额 GM 体积与知觉推理的分数相关。该数据首次显示了健康青少年受试者认知功能和冲动性的结构相关性。
