Department of Otolaryngology, Czerniakowski Hospital, Medical University of Warsaw, Warsaw, Poland.
Head Neck. 2011 Dec;33(12):1739-46. doi: 10.1002/hed.21668. Epub 2011 Jan 10.
The main goal of the study was the analysis of somatostatin receptor (SSTR) expression on juvenile nasopharyngeal angiofibroma (JNA) cells and a subsequent analysis of the utility of SST analog-based scintigraphy in JNA diagnostics.
Nine JNA cases were analyzed. All tissue samples were analyzed for the expression of SSTRs. In 2 cases, scintigraphy was performed after the intravenous (IV) administration of an SST analog. MRI of the craniofacial region was subsequently performed.
The SST analogues were accumulated in areas matching pathologic tissue in the nasopharynx. Immunohistochemical evaluation of the tissue samples proved the overexpression of SSTRs.
SSTRs are overexpressed on JNA cells. The SST analog (99m)TC-octreotide is effectively bound to JNA cells. SST analogues might be used in the diagnostics and treatment of primary, recurrent, or residual JNA.
本研究的主要目的是分析少年鼻咽血管纤维瘤（JNA）细胞中生长抑素受体（SSTR）的表达，并随后分析基于生长抑素类似物的闪烁显像术在 JNA 诊断中的应用。
分析了 9 例 JNA 病例。所有组织样本均分析了 SSTRs 的表达情况。在 2 例病例中，静脉（IV）注射 SST 类似物后进行了闪烁显像术。随后对颅面区域进行了 MRI 检查。
SST 类似物在与鼻咽部病理组织相匹配的区域蓄积。组织样本的免疫组织化学评估证实了 SSTRs 的过度表达。
JNA 细胞过度表达 SSTRs。SST 类似物（99m）Tc-奥曲肽与 JNA 细胞有效结合。SST 类似物可用于原发性、复发性或残留 JNA 的诊断和治疗。
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