（68）镓-多柔比星PET在青少年血管纤维瘤中的应用
(68)Ga-DOTATATE PET in juvenile angiofibroma.
作者信息
Gronkiewicz Zuzanna, Kukwa Wojciech, Krolicki Leszek, Cyran-Chlebicka Agata, Pawlak Dariusz, Stankiewicz Czeslaw, Krzeski Antoni, Górnicka Barbara, Wolosz Dominika, Kunikowska Jolanta
机构信息
Department of Otorhinolaryngology, Faculty of Medicine & Dentistry, Medical University of Warsaw, 19/25 Stepinska Street, 00-739 Warsaw, Poland.
Nuclear Medicine Department, Medical University of Warsaw, 1a Banacha Street, 02-097 Warsaw, Poland.
出版信息
Future Oncol. 2016 Jun;12(12):1483-91. doi: 10.2217/fon-2015-0074. Epub 2016 Mar 14.
BACKGROUND
As somatostatin receptors (SSTRs) may be overexpressed in rapidly growing vessels, the aim of this study was the analysis of in vivo and in vitro SSTR2A expression in juvenile angiofibroma (JA).
MATERIAL & METHODS: A group of six male adolescents with a diagnosis of primary, recurrent/residual JA was enrolled in the study. All patients underwent (68)Ga-DOTATATE PET/computed tomography (CT) followed by immunohistochemical staining for SSTR expression.
RESULTS
(68)Ga-DOTATATE PET/CT showed accumulation in areas matching the pathologic tissue in the nasopharynx of all patients studied with SUVmax of 5.1 ± 0.9 (ranging from 3.6 to 6.4). In all cases, the immunohistochemical examination showed a presence of SSTR2A with a high staining index.
CONCLUSION
In vitro SSTR2A cytoplasm expression was found to be high in all tumor specimens. However, the uptake of (68)Ga-DOTATATE was weak in the PET/CT studies. We postulate that the intracellular localization of the SSTR2A in JA may cause this discrepancy.
背景
由于生长迅速的血管中生长抑素受体（SSTRs）可能过度表达，本研究旨在分析青少年血管纤维瘤（JA）中SSTR2A的体内和体外表达情况。
材料与方法
本研究纳入了一组6名诊断为原发性、复发性/残留性JA的男性青少年。所有患者均接受了（68）Ga-DOTATATE正电子发射断层扫描/计算机断层扫描（PET/CT），随后进行SSTR表达的免疫组织化学染色。
结果
（68）Ga-DOTATATE PET/CT显示，所有研究患者鼻咽部与病理组织相符的区域均有放射性浓聚，SUVmax为5.1±0.9（范围为3.6至6.4）。在所有病例中，免疫组织化学检查显示存在高染色指数的SSTR2A。
结论
在所有肿瘤标本中均发现体外SSTR2A细胞质表达较高。然而，在PET/CT研究中，（68）Ga-DOTATATE的摄取较弱。我们推测JA中SSTR2A的细胞内定位可能导致了这种差异。
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