从越南采集的裂叶紫玉盘（番荔枝科）中的细胞毒性和抗微生物阿朴啡生物碱。
Cytotoxic and antimicrobial aporphine alkaloids from Fissistigma poilanei (Annonaceae) collected in Vietnam.
机构信息
Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
出版信息
Nat Prod Res. 2012;26(14):1296-302. doi: 10.1080/14786419.2011.570761. Epub 2011 Nov 11.
Two new aporphine alkaloids: 8-hydroxy-9-methoxy-1,2-methylenedioxyaporphine (1) and 8-hydroxy-3,9-dimethoxy-1,2-methylenedioxyaporphine (2) were isolated from the ethyl acetate extract of Fissistigma poilanei along with five known compounds: oxocrebanine (3), kuafumine (4), (2R,3R)-3',4',5,7-tetrahydroxydihydroflavonol-3-O-α-L-rhamnopyranoside (5), (+)-catechin 3-O-α-L-rhamnopyranoside (6) and quercetine 3,7-dimethoxy-3'-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (7). These two new aporphine alkaloids exhibited a moderate cytotoxic activity against four human cancer cell lines (KB, Hep-G2, MCF-7, LU) as well as antimicrobial activity against Lactobacillus fermentum, Enterococcus faecium, Staphylococcus aureus and Bacillus subtillis.
从粉叶轮环藤的乙酸乙酯提取物中分离得到了两个新的阿朴啡类生物碱
8-羟基-9-甲氧基-1,2-亚甲二氧基阿朴啡（1）和 8-羟基-3,9-二甲氧基-1,2-亚甲二氧基阿朴啡（2），以及 5 个已知化合物：氧化刻叶紫堇碱（3）、卡枯定（4）、（2R,3R）-3',4',5,7-四羟基二氢黄酮醇-3-O-α-L-鼠李吡喃糖苷（5）、（+）-儿茶素 3-O-α-L-鼠李吡喃糖苷（6）和槲皮素 3,7-二甲氧基-3'-O-α-L-鼠李吡喃糖基-(1 → 2)-β-D-吡喃葡萄糖苷（7）。这两个新的阿朴啡类生物碱对 4 个人类癌细胞系（KB、Hep-G2、MCF-7、LU）表现出中等的细胞毒性活性，并且对乳酸杆菌、屎肠球菌、金黄色葡萄球菌和枯草芽孢杆菌具有抗菌活性。
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