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新型阿朴啡类生物碱类似物。

New Analogues of Aporphine Alkaloids.

机构信息

Department of Applied Chemistry, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.

出版信息

Mini Rev Med Chem. 2018;18(19):1590-1602. doi: 10.2174/1389557518666180423151426.

Abstract

Aporphine alkaloids, characterized by a heterocyclic aromatic basic skeleton, are known from different organisms and exhibit various biological activities: anti-tumor, anti-viral, anti-microbial, anti-inflammatory etc. The review gives information which provides an overview of the latest progress in the structural diversity and the biological activity of the aporphine alkaloids with their derivatives isolated from natural resource in recent years. Additionally, the synthetic approaches of aporphine alkaloids have also been reviewed.

摘要

阿朴啡生物碱具有杂环芳香基本骨架,分布于不同的生物体中,具有多种生物活性:抗肿瘤、抗病毒、抗微生物、抗炎等。本文综述了近年来从天然资源中分离得到的阿朴啡生物碱及其衍生物的结构多样性和生物活性的最新进展,并对其合成方法进行了综述。

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