Lúcio Ana Silvia Suassuna Carneiro, Almeida Jackson Roberto Guedes da Silva, Da-Cunha Emídio Vasconcelos Leitão, Tavares Josean Fechine, Barbosa Filho Jos Maria
Alkaloids Chem Biol. 2015;74:233-409. doi: 10.1016/bs.alkal.2014.09.002.
This chapter presents an overview of the chemistry and pharmacology of the alkaloids found in species of the Annonaceae family. The occurrence of alkaloids from Annonaceae species, as well as their chemical structures and pharmacological activities are summarized in informative and easy-to-understand tables. Within the Annonaceae family, the genera Annona, Duguetia, and Guatteria have led to many important publications. Valuable and comprehensive information about the structure of these alkaloids is provided. The alkaloids of the aporphine type represent the predominant group in this family. Many of the isolated alkaloids exhibit unique structures. In addition to the chemical structures, the pharmacological activities of some alkaloids are also presented in this chapter. Thus, the leishmanicidal, antimicrobial, antitumor, cytotoxic, and antimalarial activities observed for these alkaloids are highlighted. The chapter is presented as a contribution for the scientific community, mainly to enable the search for alkaloids in species belonging to the Annonaceae family.
本章概述了番荔枝科植物中发现的生物碱的化学和药理学。番荔枝科植物中生物碱的存在情况，以及它们的化学结构和药理活性，都总结在信息丰富且易于理解的表格中。在番荔枝科内，番荔枝属、杜古铁属和瓜特利亚属已产生了许多重要的出版物。提供了有关这些生物碱结构的有价值且全面的信息。阿朴啡型生物碱是该科中的主要类别。许多分离出的生物碱具有独特的结构。除了化学结构外，本章还介绍了一些生物碱的药理活性。因此，突出了这些生物碱所观察到的抗利什曼原虫、抗菌、抗肿瘤、细胞毒性和抗疟活性。本章是对科学界的一份贡献，主要是为了便于在番荔枝科植物中寻找生物碱。
