Fenot M, Sierra-Fortuny S, Maillard H, Rivet J, Celerier P
Service de dermatologie, centre hospitalier, 194, avenue Rubillard, 72000 Le Mans, France.
Ann Dermatol Venereol. 2011 Nov;138(11):736-8. doi: 10.1016/j.annder.2011.05.018. Epub 2011 Jun 30.
Multiple cutaneous osteomas are a rare complication of chronic inflammatory acne that often goes unrecognized. We report a case concerning a 35-year-old woman.
A 35-year-old woman had been treated for acne since the age of 22 years, as part of which she received two courses of oral isotretinoin. We noted the secondary appearance of several microcysts on the face for which the excision was very difficult. Curiously, these small formations did not contain keratin but were very callous. Histological examination revealed foci of osseous metaplasia, probably of postinflammatory origin. Treatment consisted solely of excision of the lesions.
Osteoma cutis comprises two distinct groups (primary and secondary). In our case, there were multiple cutaneous osteomas of the face resulting from chronic acne. The differential diagnosis was idiopathic miliary osteomatosis of the face, but this was ruled out by the young age of the patient, the improvement of the acneiform lesions under isotretinoin (confirming the initial diagnosis of acne) and the subsequent appearance of microcysts. Although there are as yet no codified treatments, excision appears to yield good results.
多发性皮肤骨瘤是慢性炎症性痤疮的一种罕见并发症，常未被识别。我们报告一例35岁女性的病例。
一名35岁女性自22岁起接受痤疮治疗，期间接受了两个疗程的口服异维A酸治疗。我们注意到其面部出现了几个微囊肿，切除非常困难。奇怪的是，这些小肿物不含角蛋白，但质地非常硬。组织学检查显示骨化生灶，可能源于炎症后。治疗仅包括切除病变。
皮肤骨瘤分为两个不同的类型（原发性和继发性）。在我们的病例中，面部多发性皮肤骨瘤由慢性痤疮引起。鉴别诊断为面部特发性粟粒性骨瘤病，但患者年轻、异维A酸治疗下痤疮样病变改善（证实最初的痤疮诊断）以及随后出现微囊肿排除了该病。尽管目前尚无规范化治疗方法，但切除似乎效果良好。
