Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Epidemiol Infect. 2012 Aug;140(8):1469-80. doi: 10.1017/S095026881100224X. Epub 2011 Nov 14.
We aimed to assess differences in the prevalence of hepatitis B virus (HBV) infection in The Netherlands between 1996 and 2007, and to identify risk factors for HBV infection in 2007. Representative samples of the Dutch population in 1996 and 2007 were tested for antibodies to hepatitis B core antigen (anti-HBc), hepatitis B surface antigen (HBsAg) and HBV-DNA. In 2007, the weighted anti-HBc prevalence was 3·5% (95% CI 2·2-5·5) and the HBsAg prevalence was 0·2% (95% CI 0·1-0·4). In indigenous Dutch participants, the anti-HBc prevalence was lower in 2007 than in 1996 (P=0·06). First-generation migrants (FGMs) had a 13-fold greater risk of being HBsAg- and/or HBV-DNA-positive than indigenous Dutch participants. In indigenous Dutch participants, risk factors for anti-HBc positivity were older age and having received a blood product before 1990. In FGMs, being of Asian origin was a risk factor. In second-generation migrants, having a foreign-born partner and injecting drug use were risk factors. FGMs are the main target group for secondary HBV prevention in The Netherlands.
我们旨在评估 1996 年至 2007 年期间荷兰乙型肝炎病毒（HBV）感染的流行率差异，并确定 2007 年 HBV 感染的危险因素。1996 年和 2007 年，对荷兰代表性人群样本进行了乙型肝炎核心抗原（抗-HBc）、乙型肝炎表面抗原（HBsAg）和 HBV-DNA 抗体检测。2007 年，加权抗-HBc 流行率为 3.5%（95%CI 2.2-5.5），HBsAg 流行率为 0.2%（95%CI 0.1-0.4）。在土生土长的荷兰参与者中，2007 年的抗-HBc 流行率低于 1996 年（P=0.06）。第一代移民（FGMs）HBsAg 和/或 HBV-DNA 阳性的风险比土生土长的荷兰参与者高 13 倍。在土生土长的荷兰参与者中，抗-HBc 阳性的危险因素是年龄较大和 1990 年前接受过血液制品。在 FGMs 中，亚洲血统是一个危险因素。在第二代移民中，有外国出生的伴侣和注射吸毒是危险因素。FGMs 是荷兰二级 HBV 预防的主要目标人群。
