Kiciński Krzysztof, Skorek Andrzej, Stankiewicz Czesław
Otolaryngol Pol. 2011 Sep-Oct;65(5):326-32. doi: 10.1016/S0030-6657(11)70721-1.
The coincidence of malignant disease during pregnancy is uncommon. The incidence of cancer in pregnancy has increased, due to the tendency to postpone childbirth to an older age. Cancer complicates approximately 0.1% of all pregnancies. Managing head and neck cancers during pregnancy requires additional pregnancy-related understanding of the aetiological effect of pregnancy on cancer, knowledge of the direct and indirect effects of cancer on pregnancy, and the effect of diagnostic and treatment modalities on pregnancy. The timing of treatment is an important determinant on foetal wellbeing. A multidisciplinary approach should be adopted to enable parents and clinicians to make the best clinical decision. Clinicians must be cognizant with the ethical dilemmas of treatment. In head and neck cancers, pregnancy has no effect on maternal prognosis when compared to non-pregnant patients matched by age, cancer stage and treatment.
孕期合并恶性疾病并不常见。由于生育年龄推迟的趋势，孕期癌症的发病率有所上升。癌症在所有妊娠中所占比例约为0.1%。孕期管理头颈部癌症需要额外了解妊娠对癌症的病因学影响、癌症对妊娠的直接和间接影响以及诊断和治疗方式对妊娠的影响。治疗时机是胎儿健康的重要决定因素。应采用多学科方法，使父母和临床医生能够做出最佳临床决策。临床医生必须认识到治疗中的伦理困境。在头颈部癌症中，与年龄、癌症分期和治疗相匹配的非妊娠患者相比，妊娠对母亲预后没有影响。
