[系统性自身免疫性疾病与抑郁症]

[Systemic autoimmune diseases and depressive disorders].

作者信息

Arias Sylvia, Fonsalía Victoria, Asteggiante Nicolás, Bartesaghi Verónica

机构信息

Policlínica de Enfermedades Autoinmunes Sistémicas, Hospital Maciel, Montevideo, Uruguay.

出版信息

Reumatol Clin. 2011 Nov-Dec;7(6):389-91. doi: 10.1016/j.reuma.2011.04.010. Epub 2011 Jun 30.

DOI:10.1016/j.reuma.2011.04.010

PMID:22078697

Abstract

INTRODUCTION

The incidence of depression accompanying medical pathologies is elevated and have prognostic importance.

OBJECTIVE

To determine the frequency of depression in patients with systemic autoimmune diseases (SAD), as well as to determine the frequency of pain, fatigue and sleep disorders in these patients and their relation with depression.

MATERIAL AND METHODS

We performed a descriptive, prospective study on 88 patients with AID. The CES-D depression questionnaire, FSS fatigue questionnaire and the Pittsburgh sleep quality index were administered.

RESULTS

69% (n=61) of patients were depressed. Pain was found in 97% (59/61) of depressed patients and in 62% (17/27) of non-depressed patients (P=.0006). Sleep disorders were found in 95% of depressed patients, whereas 60% of non-depressed patients presented them (P=.00008). Depression was associated with fatigue: 80% (49/61) for depressed and 44% for non-depressed (p=0,001) persons.

DISCUSSION

A very elevated prevalence of depression was found in SAD: 69%; constituting the most frequent comorbidity. Depression was significantly associated with pain, fatigue and sleep disorders.

摘要

引言

伴随医学病症出现的抑郁症发病率有所上升，且具有预后重要性。

目的

确定系统性自身免疫性疾病（SAD）患者中抑郁症的发生率，以及确定这些患者中疼痛、疲劳和睡眠障碍的发生率及其与抑郁症的关系。

材料与方法

我们对88例自身免疫性疾病患者进行了一项描述性前瞻性研究。采用了流调中心用抑郁量表（CES-D）、疲劳量表（FSS）和匹兹堡睡眠质量指数进行评估。

结果

69%（n = 61）的患者患有抑郁症。在抑郁症患者中，97%（59/61）存在疼痛，在非抑郁症患者中，62%（17/27）存在疼痛（P = 0.0006）。95%的抑郁症患者存在睡眠障碍，而60%的非抑郁症患者存在睡眠障碍（P = 0.00008）。抑郁症与疲劳相关：抑郁症患者中80%（49/61）存在疲劳，非抑郁症患者中44%存在疲劳（p = 0.001）。