Friel J K, Andrews W L, Matthew J D, Long D R, Cornel A M, Cox M, Skinner C T
Department of Biochemistry, Memorial University of Newfoundland, St. John's.
CMAJ. 1990 Oct 15;143(8):733-7.
The adequacy of iron stores in infants of very low birth weight (defined as less than 1500 g) in Canada is unknown. We monitored the iron status of 81 such infants at 3, 6, 9, 12 and 15 months of age. All of the infants were fed formula fortified with iron (13 mg/L) for at least 6 months, starting at 2 months of age. The plasma ferritin level decreased after the formula was no longer used. Although 90% of the infants were given cereal fortified with iron (30 mg of iron per 100 g) by 9 months of age, the plasma ferritin level continued to decrease. The level was less than 10 micrograms/L in 54% of the infants at 12 months of age and in 74% at 15 months; this indicated depleted iron stores. Because of delayed development very-low-birth-weight infants eat small amounts of cereal and therefore require iron-fortified formula throughout infancy.
加拿大极低出生体重儿(定义为出生体重低于1500克)的铁储备充足情况尚不清楚。我们监测了81名此类婴儿在3、6、9、12和15月龄时的铁状况。所有婴儿从2月龄开始至少6个月喂养强化铁(13毫克/升)的配方奶。停止使用配方奶后,血浆铁蛋白水平下降。尽管到9月龄时90%的婴儿食用了强化铁(每100克含30毫克铁)的谷物,但血浆铁蛋白水平仍持续下降。12月龄时54%的婴儿以及15月龄时74%的婴儿该水平低于10微克/升;这表明铁储备耗竭。由于发育迟缓,极低出生体重儿食用的谷物量少,因此在整个婴儿期都需要强化铁配方奶。