State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China.
Biochem Biophys Res Commun. 2011 Dec 2;415(4):608-12. doi: 10.1016/j.bbrc.2011.10.118. Epub 2011 Oct 31.
Neuritin (NRN1), a neurotrophic factor, plays an important role in neurite growth and neuronal survival. In this study, we identify a new function of neuritin as a novel angiogenic factor in vitro and in vivo. Recombinant neuritin protein had no effect on the proliferation and adhesion of human umbilical vein endothelial cells (HUVEC), but it dose-dependently increased endothelial cell migration. Furthermore, overexpression of neuritin significantly promoted tumor angiogenesis, and surprisingly, it inhibited tumor growth in a xenograft tumor model. Thus, our results indicate that neuritin may act as an important angiogenic factor and serve as a potential target for cancer therapy.
神经调节蛋白 1（NRN1）是一种神经营养因子，在轴突生长和神经元存活中发挥重要作用。在这项研究中，我们发现神经调节蛋白 1 具有作为一种新型血管生成因子的新功能，无论是在体外还是体内。重组神经调节蛋白蛋白对人脐静脉内皮细胞（HUVEC）的增殖和黏附没有影响，但它能剂量依赖性地增加内皮细胞迁移。此外，神经调节蛋白 1 的过表达显著促进了肿瘤血管生成，令人惊讶的是，它还抑制了异种移植肿瘤模型中的肿瘤生长。因此，我们的研究结果表明，神经调节蛋白 1 可能作为一种重要的血管生成因子发挥作用，并可能成为癌症治疗的潜在靶点。
