基于外周血和基因表达作为胃癌的微创生物标志物
Peripheral Blood-based and Gene Expression as Minimally Invasive Biomarkers for Gastric Cancer.
作者信息
Queiroz Daniel Soares, Santos Yeda Beatriz Louredo, Santos Leonardo Caires, Chen Elizabeth Suchi, Gigek Carolina Oliveira, Lourenço Laercio Gomes, Arasaki Carlos Haruo, Artigiani Ricardo, Forones Nora Manoukian, Smith Marilia Arruda Cardoso, Wisnieski Fernanda
机构信息
Discipline of Gastroenterology, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Discipline of Genetics, Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil.
出版信息
In Vivo. 2025 Sep-Oct;39(5):2646-2658. doi: 10.21873/invivo.14065.
BACKGROUND/AIM: Gastric cancer (GC) remains one of the most common and fatal cancer types worldwide. Herein, we explored neuritin 1 () and tumor necrosis factor alpha-induced protein 3 () as minimally invasive biomarkers of GC.
MATERIALS AND METHODS
The and mRNA levels in the peripheral blood samples of 42 patients with GC were compared with 12 individuals with no cancer diagnosis, and monitored after gastrectomy.
RESULTS
expression was elevated in patients compared with controls (<0.01), and was able to discriminate between these groups (area under the curve=0.72, =0.02). After resection of the primary tumor, expression decreased (<0.01), reaching levels observed in controls. expression showed no difference between patients and controls, nor postoperatively.
CONCLUSION
Peripheral blood-based expression can be used as a minimally invasive biomarker for GC detection and postoperative monitoring.
背景/目的：胃癌（GC）仍然是全球最常见且致命的癌症类型之一。在此，我们探索了神经生长因子1（）和肿瘤坏死因子α诱导蛋白3（）作为胃癌的微创生物标志物。
材料与方法
将42例胃癌患者外周血样本中的和mRNA水平与12例未患癌症的个体进行比较，并在胃切除术后进行监测。
结果
与对照组相比，患者中的表达升高（<0.01），并且能够区分这些组（曲线下面积=0.72，=0.02）。切除原发性肿瘤后，表达降低（<0.01），达到对照组中观察到的水平。患者与对照组之间以及术后的表达均无差异。
结论
基于外周血的表达可作为胃癌检测和术后监测的微创生物标志物。
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