Baud J-M, Matrand G, Georges J-L, Beaufils P, Livarek B
Unité de Médecine Vasculaire, Service de Cardiologie, Hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
J Mal Vasc. 2011 Dec;36(6):386-94. doi: 10.1016/j.jmv.2011.10.003. Epub 2011 Nov 10.
To assess the most accurate clinical signs and clinical scoring for selecting patients who could benefit from duplex sonography screening of deep venous thrombosis (DVT) after total hip replacement (THR) and total knee replacement (TKR).
Four hundred and eighty consecutive patients with THR or TKR were included. Post-operative physical examination and venous duplex sonography (day 6-10) were performed in all of them. DVT was diagnosed in presence of at least 3mm thick and 3 cm long incomplete venous compressibility. Clinical prediction scores were built from clinical parameters, which were significantly associated with DVT in univariate analysis, one of them weighted from logistic multivariate regression coefficients.
Recent DVT was diagnosed in 74 patients (15.7%) (29.6% after TKR and 8.4% after THR). There was no isolated proximal DVT and extensive DVTs were very rare (TKR 1.2% vs. THR 1%). Two TKR patients developed pulmonary embolism (1.2%). One died (0.6%). Univariate analysis showed significant association between provoked localized limb pain, pitting edema and difference in calf circumference (DCC), and DVT (P<0.0001). DCC> 3 cm was significantly associated with DVT (32.4% vs. 16.6%, OR 2.4 [1.3-4.2] ; P=0.001). In multivariate analysis the only two clinical manifestations independently associated with DVT were provoked localized limb pain (adjusted OR 2.3 [1.3-4.1] ; P<0.01) and DCC> 3 cm (adjusted OR 2.0 [1.1-3.8] ; P=0.04). A clinical score value greater or equal to 4 was associated with a risk of DVT of 34%, and a value<4 with a risk of 9%.
After THR or TKR, DCC> 3 cm or a clinical risk score greater or equal to 4 could be used as an accurate and easy clinical test for assessing the need for further DVT screening by sonography.
评估在全髋关节置换术(THR)和全膝关节置换术(TKR)后,用于选择可能从双功超声筛查深静脉血栓形成(DVT)中获益的患者的最准确临床体征和临床评分。
纳入480例连续接受THR或TKR的患者。对所有患者进行术后体格检查和静脉双功超声检查(第6 - 10天)。当存在至少3mm厚且3cm长的不完全静脉压缩时诊断为DVT。临床预测评分由临床参数构建,这些参数在单因素分析中与DVT显著相关,其中一个参数根据逻辑多元回归系数加权。
74例患者(15.7%)诊断为近期DVT(TKR后为29.6%,THR后为8.4%)。无孤立的近端DVT,广泛DVT非常罕见(TKR为1.2%,THR为1%)。2例TKR患者发生肺栓塞(1.2%)。1例死亡(0.6%)。单因素分析显示,激发性局部肢体疼痛、凹陷性水肿和小腿周径差异(DCC)与DVT之间存在显著关联(P<0.0001)。DCC>3cm与DVT显著相关(32.4%对16.6%,OR 2.(1.3 - 4.2);P = 0.001)。在多因素分析中,与DVT独立相关的仅有的两个临床表现是激发性局部肢体疼痛(校正OR 2.3((1.3 - 4.1);P<0.01)和DCC>3cm(校正OR 2.0(1.1 - 3.8);P = 0.04)。临床评分值大于或等于4与DVT风险34%相关,评分值<4与DVT风险9%相关。
在THR或TKR后,DCC>3cm或临床风险评分大于或等于4可作为一种准确且简便的临床检查,用于评估是否需要进一步进行超声DVT筛查。