Bershteĭn L M, Tsyrlina E V, Semiglazov V F, Valdina E A, L'vovich E G
Vopr Med Khim. 1979 Mar-Apr;25(2):144-8.
Excretion of cholesterol with urine was studied using gas chromatography in healthy persons, in patients with cancer of mammary glands, fibroadenoma, lung carcinoma and in patients with beningn processes in lungs. Cholesterol excretion was not increased in patients with the malignant tumors studied. In patients with the cancer of mammary glands and lung carcinoma normal correlation was altered between excretion of cholesterol with urine and content of lipoproteins, protein-bound iodine, 11-hydroxycorticosteroids in blood as well as excretion of cyclic AMP with urine. Treatment with euphylline was accompanied by a decrease in cholesteroluria in patients with fibroadenoma but the drug had no comparable effect on patients with the cancer of mammary glands. In patients with the cancer of mammary glands phenphormine caused distinct decrease and misclerone--moderate increase in excretion of cholesterol with urine.
采用气相色谱法对健康人、乳腺癌患者、纤维腺瘤患者、肺癌患者以及肺部良性病变患者的尿胆固醇排泄情况进行了研究。在所研究的恶性肿瘤患者中，胆固醇排泄并未增加。在乳腺癌和肺癌患者中，尿胆固醇排泄与血液中脂蛋白、蛋白结合碘、11-羟皮质类固醇含量以及尿中环磷酸腺苷排泄之间的正常相关性发生了改变。用氨茶碱治疗时，纤维腺瘤患者的尿胆固醇排泄减少，但该药物对乳腺癌患者没有类似作用。在乳腺癌患者中，苯乙双胍使尿胆固醇排泄明显减少，而米斯克洛酮使尿胆固醇排泄适度增加。
