Kal'nova N Iu, Pal'mina N P
Vopr Med Khim. 1981;27(4):510-3.
Phospholipid composition and antioxidative activity of lipids were studied in blood plasma of patients with tumoral and nonmalignant pathologies of mammary glands. In patients with mammary gland tumors relative content of various phospholipids was distinctly altered as compared with healthy persons. Specific alterations in content of the phospholipids were noted at various steps of the pathological process: an increase in content of sphingomyelin and complete absence of lysophosphatidyl choline in fibroadenoma; the same phenomenon, simultaneously with an increase in content of phosphatidyl ethanolamine and a decrease in phosphatidyl choline concentration, was observed in fibrocystic mastopathy. At the initial steps of malignization lysophosphatidyl choline was not found but the sphingomyelin contents were of opposite direction as compared with fibrocystic mastopathy. The subsequent development of neoplasm was characterized by an increase in relative content of sphingomyelin/in patients with tumors up to 4 cm in diameter (as well as of phosphatidyl ethanolamine and by a decrease in lysophosphatidyl choline content) tumors exceeding 5 cm/ as compared with the normal state. The antioxidative activity of blood plasma lipids was significantly decreased in patients with non-malignant tumors and with malignant neoplasms exceeding 6 cm in diameter. An X-ray treatment altered the lipid fraction antioxidative activity and relative content of erythrocyte phospholipids towards the states typical for early steps of malignization.
对患有乳腺肿瘤和非恶性乳腺疾病患者的血浆中磷脂成分和脂质抗氧化活性进行了研究。与健康人相比，乳腺肿瘤患者各种磷脂的相对含量明显改变。在病理过程的不同阶段观察到磷脂含量的特定变化：纤维腺瘤中鞘磷脂含量增加而溶血磷脂酰胆碱完全缺失；在纤维囊性乳腺病中观察到同样的现象，同时磷脂酰乙醇胺含量增加而磷脂酰胆碱浓度降低。在恶性肿瘤形成的初始阶段未发现溶血磷脂酰胆碱，但与纤维囊性乳腺病相比，鞘磷脂含量变化趋势相反。肿瘤的后续发展特征为鞘磷脂相对含量增加（直径达4厘米的肿瘤患者中）（以及磷脂酰乙醇胺增加，溶血磷脂酰胆碱含量降低）（与正常状态相比，直径超过5厘米的肿瘤）。非恶性肿瘤患者以及直径超过6厘米的恶性肿瘤患者血浆脂质的抗氧化活性显著降低。X射线治疗使脂质部分的抗氧化活性和红细胞磷脂的相对含量朝着恶性肿瘤形成早期阶段的典型状态改变。
