Research Service (151-JC), St. Louis Veterans Affairs Medical Center, St. Louis, MO, USA.
Nicotine Tob Res. 2012 Apr;14(4):415-24. doi: 10.1093/ntr/ntr230. Epub 2011 Nov 11.
Smoking is a well-established correlate of suicidal behavior. It is not known if familial risk factors contribute to this association.
Data were obtained via semistructured interviews with 1,107 twin fathers, 1,919 offspring between ages 12-32 years, and 1,023 mothers. Familial vulnerability to nicotine dependence and suicidal behavior was modeled via father and maternal self-report of these behaviors. Multinomial logistic regression models were computed with and without familial risk factors to estimate the association between offspring ever smoking, regular smoking, nicotine dependence, and a 4-level offspring suicide variable: (a) none, (b) ideation, (c) ideation + plan, and (d) ideation + plan + attempt or ideation + attempt. All models were stratified by gender and adjusted for sociodemographics, familial risk factors including parental suicidal behavior, nicotine dependence, and conduct disorder, and offspring conduct disorder, depression, alcohol abuse/dependence, and illicit drug abuse/dependence.
After adjusting for covariates and familial risk factors, ever smoking was not significantly associated with suicidal behavior in males and females. In males, regular smoking was associated with ideation + plan (odds ratio [OR] = 5.47; 95% CI: 1.05-28.60), and in females, regular smoking was associated with ideation + plan + attempt or ideation + attempt. In both genders, nicotine-dependent smoking was associated with ideation + plan + attempt or ideation + attempt (males: OR = 6.59; 95% CI: 1.91-22.70, females: OR = 3.37; 95% CI: 1.25-9.04). Comparison of models with and without familial risk factors indicated that there is no mediation of smoking status and suicidal behavior by familial risk.
Smoking and nicotine dependence are correlated with suicidal behaviour. Contributions from familial risk factors did not significantly alter this association.
吸烟是自杀行为的一个既定相关因素。目前尚不清楚家族危险因素是否会促成这种关联。
通过对 1107 对双胞胎父亲、1919 名年龄在 12-32 岁之间的子女和 1023 名母亲进行半结构化访谈，获得了数据。通过父亲和母亲对这些行为的自我报告，对尼古丁依赖和自杀行为的家族易感性进行建模。使用包含和不包含家族危险因素的多项逻辑回归模型来估计后代是否吸烟、经常吸烟、尼古丁依赖与后代自杀的 4 级变量之间的关联：(a)无，(b)有自杀意念，(c)有自杀意念+计划，(d)有自杀意念+计划+尝试或有自杀意念+尝试。所有模型都按性别分层，并根据社会人口统计学、包括父母自杀行为、尼古丁依赖和品行障碍在内的家族危险因素以及后代品行障碍、抑郁、酒精滥用/依赖和非法药物滥用/依赖进行调整。
在调整了协变量和家族危险因素后，吸烟与男性和女性的自杀行为没有显著关联。在男性中，经常吸烟与有自杀意念+计划有关（优势比[OR] = 5.47；95%置信区间[CI]：1.05-28.60），而在女性中，经常吸烟与有自杀意念+计划+尝试或有自杀意念+尝试有关。在两种性别中，尼古丁依赖吸烟与有自杀意念+计划+尝试或有自杀意念+尝试有关（男性：OR = 6.59；95% CI：1.91-22.70，女性：OR = 3.37；95% CI：1.25-9.04）。有和没有家族危险因素的模型之间的比较表明，家族危险因素并没有对吸烟状况和自杀行为的关联进行中介。
吸烟和尼古丁依赖与自杀行为相关。家族危险因素的贡献并没有显著改变这种关联。
