Maggio L, Hoffman R, Cotter S M, Dainiak N, Mooney S, Maffei L A
Yale J Biol Med. 1978 Jul-Aug;51(4):469-76.
In man, hematologic abnormalities precede the development of acute myeloblastic leukemia in about one-third of individuals. This preleukemic state may represent a stage of adult leukemia wherein small numbers of leukemic cells are present and the normal marrow stem cell compartment has not been seriously compromised. A syndrome resembling human preleukemia occurs in cats infected with feline leukemia virus (FeLV). This disorder is characterized by anemia, leukopenia or thrombocytopenia occurring weeks or months prior to the development of feline acute leukemia. The natural occurrence of this syndrome in this domestic animal population makes it a potential model of human preleukemia. Initial poor results of therapy of human preleukemia presently prohibit one from carrying out controlled trials with chemotherapeutic agents in such a group of patients. Preliminary trials with chemo- and/or immunotherapy may be more easily attempted with FeLV infected preleukemic cats.
在人类中，约三分之一的个体在急性髓细胞白血病发生之前会出现血液学异常。这种白血病前期状态可能代表成人白血病的一个阶段，其中存在少量白血病细胞，且正常骨髓干细胞池尚未受到严重损害。感染猫白血病病毒（FeLV）的猫会出现一种类似于人类白血病前期的综合征。这种疾病的特征是在猫急性白血病发生前数周或数月出现贫血、白细胞减少或血小板减少。这种综合征在该家畜群体中的自然发生使其成为人类白血病前期的潜在模型。目前人类白血病前期治疗的初步效果不佳，使得无法在这类患者中进行化疗药物的对照试验。使用感染FeLV的白血病前期猫进行化疗和/或免疫治疗的初步试验可能更容易尝试。
