Shukla Y, Antony M, Kumar S, Mehrotra N K
Laboratory of Environmental Carcinogenesis, Industrial Toxicology Research Centre, Lucknow, India.
Cancer Lett. 1990 Sep;53(2-3):191-5. doi: 10.1016/0304-3835(90)90213-h.
Mancozeb, a polymeric complex of ethylene bis (dithiocarbamate) manganese with zinc salt is a protective fungicide. In the present study complete carcinogenic activity of mancozeb, has been observed following topical application on dorsal mouse skin. Female Swiss albino mice were exposed to mancozeb at a dose of 100 mg/kg body weight dissolved in 100 microliters dimethyl sulfoxide 3 times per week. Development of tumours was observed after 31 weeks (217 days) of mancozeb application. A high rate of mortality was observed after 54 weeks (378 days) of mancozeb application due to its toxicity and the study was terminated after 60 weeks. On histological examination, these tumours were found mostly to be benign in nature, e.g., squamous cell papillomas and keratoacanthomas.
代森锰锌是一种乙撑双（二硫代氨基甲酸酯）锰与锌盐的聚合络合物，是一种保护性杀菌剂。在本研究中，将代森锰锌局部涂抹于小鼠背部皮肤后，观察到了其完全致癌活性。雌性瑞士白化小鼠每周3次暴露于溶解在100微升二甲基亚砜中的代森锰锌，剂量为100毫克/千克体重。在施用代森锰锌31周（217天）后观察到肿瘤的发生。由于其毒性，在施用代森锰锌54周（378天）后观察到高死亡率，该研究在60周后终止。经组织学检查，这些肿瘤大多为良性，如鳞状细胞乳头状瘤和角化棘皮瘤。
