Department of Physics and Center for Nano and Molecular Science and Technology, The University of Texas at Austin, Austin, Texas 78712, USA.
Nat Mater. 2011 Nov 13;11(1):69-75. doi: 10.1038/nmat3161.
Engineered optical metamaterials present a unique platform for biosensing applications owing to their ability to confine light to nanoscale regions and to their spectral selectivity. Infrared plasmonic metamaterials are especially attractive because their resonant response can be accurately tuned to that of the vibrational modes of the target biomolecules. Here we introduce an infrared plasmonic surface based on a Fano-resonant asymmetric metamaterial exhibiting sharp resonances caused by the interference between subradiant and superradiant plasmonic resonances. Owing to the metamaterial's asymmetry, the frequency of the subradiant resonance can be precisely determined and matched to the molecule's vibrational fingerprints. A multipixel array of Fano-resonant asymmetric metamaterials is used as a platform for multispectral biosensing of nanometre-scale monolayers of recognition proteins and their surface orientation, as well as for detecting chemical binding of target antibodies to recognition proteins.
基于表面等离激元的人工超材料为生物传感应用提供了一个独特的平台，因为它们能够将光限制在纳米区域，并具有光谱选择性。红外等离子体超材料尤其具有吸引力，因为它们的共振响应可以精确地调谐到目标生物分子的振动模式。在这里，我们介绍了一种基于 Fano 共振非对称超材料的红外等离子体表面，该表面表现出由亚辐射和超辐射等离子体共振干涉引起的尖锐共振。由于超材料的不对称性，可以精确地确定亚辐射共振的频率，并将其与分子的振动指纹相匹配。一个 Fano 共振非对称超材料的多像素阵列被用作纳米尺度识别蛋白单层及其表面取向的多光谱生物传感平台，以及用于检测目标抗体与识别蛋白的化学结合。
