通过二乙烯基吡咯啉的电环化闭环反应全合成（±）-γ-石蒜烷。
Total synthesis of (±)-γ-lycorane via the electrocyclic ring closure of a divinylpyrroline.
作者信息
Huntley Raymond J, Funk Raymond L
机构信息
Department of Chemistry, Pennsylvania State University, University Park, Pennsylvaia, 16802, USA.
出版信息
Tetrahedron Lett. 2011 Dec 14;52(50):6671-6674. doi: 10.1016/j.tetlet.2011.09.138.
Abstract
A concise total synthesis of (±)-γ-lycorane is described. The key step in the synthesis is the 6π-electrocyclic ring closure of a divinylpyrroline to give a tetrahydroindole, which is subsequently hydrogenated to give the all-cis indolizidine core.
摘要
本文描述了(±)-γ-石蒜碱的简洁全合成方法。该合成的关键步骤是二乙烯基吡咯啉的6π-电环化闭环反应生成四氢吲哚，随后将其氢化得到全顺式中氮茚核心。
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