Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.
Org Lett. 2010 Dec 17;12(24):5768-71. doi: 10.1021/ol102693e. Epub 2010 Nov 19.
A diastereoselective 6π-electrocyclic ring closure employing halogen-substituted 3-amidotrienes via a 1,6-remote asymmetric induction is described. This new asymmetric manifold for pericyclic ring closure further underscores the significance of the allenamide chemistry.
通过 1,6-远程不对称诱导,利用卤素取代的 3-酰胺三烯进行非对映选择性 6π-电环化环封闭反应。这种新的不对称的周环环合方法进一步强调了 Allenamide 化学的重要性。