Donald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA.
Autophagy. 2011 Dec;7(12):1573-4. doi: 10.4161/auto.7.12.18175.
Recent publications link mitophagy mediated by PINK1 and Parkin with cardioprotection and attenuation of inflammation and cell death. The field is in need of methods to monitor mitochondrial turnover in vivo to support the development of new therapies targeting mitochondrial turnover.
最近的出版物将 PINK1 和 Parkin 介导的线粒体自噬与心脏保护以及炎症和细胞死亡的减轻联系起来。该领域需要能够在体内监测线粒体周转率的方法,以支持针对线粒体周转率的新疗法的开发。