使用聚类热图研究 HIV 感染和未感染儿童和青年人体成分与实验室测量值之间的关系。
Using cluster heat maps to investigate relationships between body composition and laboratory measurements in HIV-infected and HIV-uninfected children and young adults.
机构信息
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA.
出版信息
J Acquir Immune Defic Syndr. 2012 Mar 1;59(3):325-8. doi: 10.1097/QAI.0b013e31823fdbec.
Abstract
Cluster heat maps were used to investigate relationships between body composition, lipid levels, and glucose metabolism in HIV-infected and HIV-uninfected children and young adults using data from a cross-sectional study. Three distinct clusters of participants were identified. One group had lower body fat and higher lipid measures and was mostly HIV infected. The other 2 groups were a mix of HIV-infected and HIV-uninfected participants. Of these, 1 cluster had more participants with higher body fat and insulin resistance, which are risk factors for future cardiovascular disease, and the other had relatively normal measurements on all outcomes.
摘要
采用聚类热图的方法，利用横断面研究的数据，研究了 HIV 感染和未感染的儿童和年轻成人的身体成分、血脂水平和葡萄糖代谢之间的关系。研究确定了三个不同的参与者群体。一个群体的体脂较低，血脂水平较高，主要是 HIV 感染者。另外两个群体则是 HIV 感染者和 HIV 未感染者的混合。其中一个群体中，更多的参与者存在体脂较高和胰岛素抵抗的情况，这些都是未来心血管疾病的风险因素，另一个群体的所有结果的测量值相对正常。
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本文引用的文献
1
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2
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Diabetologia. 1985 Jul;28(7):412-9. doi: 10.1007/BF00280883.
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