Opavský J, Houdek M
Katedra farmakologie LF UP, Olomouc.
Cesk Neurol Neurochir. 1990 Jul;53(4):264-8.
The study evaluated the effect of intraventricular morphine administration on chronic pain associated with malignant diseases in five subjects. To facilitate repeated application of the analgesic a reservoir was fixed subcutaneously on the calvaria with the catheter tip place in the lateral ventricle. The described approach made it possible to reduce substantially the dosage and to protract the action of morphine, as compared with intramuscular administration. No serious complications developed when the described mode of application was used. Because of the technically unpretentious procedure, the simple administration into the reservoir and the significant analgetic effect this method can be used in patients with malignant pain even in advanced stages of the disease.
该研究评估了脑室内注射吗啡对5名患有恶性疾病所致慢性疼痛患者的效果。为便于重复应用镇痛剂，在颅骨上皮下固定了一个贮器，导管尖端置于侧脑室内。与肌肉注射相比，所述方法可大幅减少吗啡用量并延长其作用时间。采用所述应用方式未出现严重并发症。由于该操作技术要求不高、向贮器内给药简便且镇痛效果显著，即使在疾病晚期的恶性疼痛患者中也可使用此方法。
